Linked Life Data

2436631

Source:http://linkedlifedata.com/resource/pubmed/id/2436631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1987-4-29
pubmed:abstractText
Effects of alpha-(2,5-dimethoxyphenyl)-beta-glycinamide-ethanol hydrochloride (midodrine, ST-1085) on experimental postural hypotension was examined in hexamethonium (20 mg/kg s.c.)-treated anesthetized dogs. The dogs were tilted 30 degrees to a head-up position. A 30 degree-tilt caused a significant decrease in blood pressure. Midodrine, 0.3 mg/kg, attenuated the decrease in blood pressure induced by the tilt significantly at 10 and 30 min after administration of the drug. The heart rate increased following the tilt, but the degree of the increase was rather small. Cerebral tissue blood flow significantly decreased by the tilt. Midodrine, 0.3 mg/kg, significantly attenuated the decrease in cerebral tissue blood flow induced by the tilt at 10 and 30 min. Vertebral arterial blood flow significantly decreased by the tilt. Midodrine reduced the decrease in vertebral arterial blood flow induced by the tilt significantly at 10 and 30 min. Cardiac output also decreased significantly by the tilt. Midodrine attenuated the decrease in cardiac output significantly at 10 min. Femoral arterial blood flow decreased significantly by the tilt. Midodrine tended to reduce the decrease in femoral arterial blood flow induced by the tilt at 30 min. Therefore, midodrine via vasoconstriction seems to be useful for the decrease in blood flows due to the postural hypotension.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1748-51
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Effects of midodrine on experimentally-induced postural hypotension in dogs.
pubmed:publicationType
Journal Article