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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1986-7-15
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| pubmed:abstractText |
The effects of indoramin on cardiac conduction and its antifibrillatory action were investigated and compared with those of mexiletine (class I antiarrhythmic agent), sotalol, and prazosin. In isolated guinea pig atria, indoramin 1 microgram/ml reduced spontaneous rate by 31 +/- 1.0% (mean +/- SE, n = 6) and maximal driving frequency by 25 +/- 1.2% (n = 4). Mexiletine 3 micrograms/ml reduced maximal driving frequency by 35 +/- 1.4% (n = 4) but reduced spontaneous rate by only 13 +/- 2.0% (n = 4). In isolated, perfused, electrically driven (2.5 Hz) guinea pig hearts, indoramin 1 microgram/ml increased the ST interval by 22 +/- 1.9% (n = 6) with no effect on the QRS interval. Higher concentrations (3 micrograms/ml) also increased the QRS interval by 21 +/- 4.0%. In anaesthetized cats, indoramin 6 mg/kg i.v. (infused over 30 min) reduced systolic blood pressure by 36 +/- 3.6% (n = 6) and heart rate by 35 +/- 2.2%, and increased the ST interval by 31 +/- 5.3% and the effective refractory period by 45 +/- 3.2% but had little or no effect on the QRS interval (12 +/- 2.9%) and diastolic electrical stimulation threshold (7 +/- 6.8%). Indoramin 10 mg/kg increased the QRS interval and diastolic electrical stimulation threshold by 20 +/- 2.8 and 23 +/- 2.5%, respectively. Analogous experiments with mexiletine 15 mg/kg showed little changes in cycle length (7 +/- 1.3%), effective refractory period (21 +/- 2.8%), and the ST interval (6 +/- 2.5%); however, there was a marked increase in diastolic threshold (91 +/- 8.9%). Sotalol 15 mg/kg had a cardiac profile similar to that of indoramin.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Indoramin,
http://linkedlifedata.com/resource/pubmed/chemical/Mexiletine,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Sotalol
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| pubmed:status |
MEDLINE
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| pubmed:issn |
0160-2446
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
8 Suppl 2
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S131-6
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:2423786-Animals,
pubmed-meshheading:2423786-Arrhythmias, Cardiac,
pubmed-meshheading:2423786-Blood Pressure,
pubmed-meshheading:2423786-Cats,
pubmed-meshheading:2423786-Coronary Vessels,
pubmed-meshheading:2423786-Electrocardiography,
pubmed-meshheading:2423786-Guinea Pigs,
pubmed-meshheading:2423786-Heart,
pubmed-meshheading:2423786-Heart Rate,
pubmed-meshheading:2423786-Indoles,
pubmed-meshheading:2423786-Indoramin,
pubmed-meshheading:2423786-Mexiletine,
pubmed-meshheading:2423786-Myocardial Contraction,
pubmed-meshheading:2423786-Prazosin,
pubmed-meshheading:2423786-Rats,
pubmed-meshheading:2423786-Sotalol
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| pubmed:year |
1986
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| pubmed:articleTitle |
Experimental evidence for the antiarrhythmic action of indoramin.
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| pubmed:publicationType |
Journal Article
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