Linked Life Data

2421825

Source:http://linkedlifedata.com/resource/pubmed/id/2421825

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1986-5-30
pubmed:abstractText
The physiological effects of dihydroavermectin B1 on insect central neurones have been investigated using a culture system derived from the brains of embryonic cockroaches. In these neuronal cultures 60% of the cells respond to the application of gamma-aminobutyric acid (GABA) with a conductance increase; these responses are blocked by picrotoxin but not by bicuculline. Dihydroavermectin B1, a representative of a potentially new class of insecticide, also produces a slow conductance increase which is blocked by picrotoxin and inverted by the injection of chloride ions. Qualitatively similar responses are also evoked by dihydroavermectin B1 in some neurones unaffected by GABA and in neurones exposed to elevated Mg2+ concentrations to inhibit synaptic release mechanisms. In a subpopulation of neurones dihydroavermectin B1 evokes a transient, initial excitation prior to the apparent chloride conductance increase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
366
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-72
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Dihydroavermectin B1: actions on cultured neurones from the insect central nervous system.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't