rdf:type |
|
lifeskim:mentions |
umls-concept:C0003342,
umls-concept:C0014644,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024264,
umls-concept:C0031858,
umls-concept:C0332206,
umls-concept:C0795760,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
pubmed:issue |
1
|
pubmed:dateCreated |
1986-5-22
|
pubmed:abstractText |
Acute infectious mononucleosis (IM) is accompanied by measurable abnormalities of immune function, including a transient immunosuppression. The sera of patients with acute IM contain an IgG blocking factor which binds to T-lymphocytes and decreases their responses to antigens and mitogens. The experiments reported herein indicate that isoprinosine, an immunopotentiating agent, can reverse this inhibition of T cells by IM-associated IgG blocking factor. Isoprinosine may be a useful tool in understanding the interactions between blocking factors and lymphocytes; moreover, isoprinosine may be of value in patients with abnormal clinical responses to Epstein-Barr virus (EBV) such as chronic IM or persistent active EBV infections.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0192-0561
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
101-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2420730-Antigens, Viral,
pubmed-meshheading:2420730-Cells, Cultured,
pubmed-meshheading:2420730-Herpesvirus 4, Human,
pubmed-meshheading:2420730-Humans,
pubmed-meshheading:2420730-Immunoglobulin G,
pubmed-meshheading:2420730-Infectious Mononucleosis,
pubmed-meshheading:2420730-Inosine,
pubmed-meshheading:2420730-Inosine Pranobex,
pubmed-meshheading:2420730-Lymphocyte Activation,
pubmed-meshheading:2420730-Lymphocytes,
pubmed-meshheading:2420730-Phytohemagglutinins
|
pubmed:year |
1986
|
pubmed:articleTitle |
Isoprinosine abolishes the blocking factor-mediated inhibition of lymphocyte responses to Epstein-Barr virus antigens and phytohemagglutinin.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|