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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1990-2-14
|
| pubmed:abstractText |
The dose response to a single topical administration of the carbonic anhydrase inhibitor MK-927 was investigated in 24 patients with primary open angle glaucoma or ocular hypertension. Three concentrations of MK-927 (2%, 1%, and 0.5%) and placebo were administered in a two-center, double-masked, randomized, placebo-controlled, four-period crossover study. MK-927 at the 0.5% concentration appeared to be minimally effective in reducing intraocular pressure. A single topical dose of 1% MK-927 resulted in a significantly greater percent reduction in intraocular pressure for up to 6 hours when compared with treatment with placebo. Similarly, a single dose of 2% MK-927 significantly lowered intraocular pressure for 8 hours compared with treatment with placebo. The pressure reduction from baseline measured 23.7% and 11.3% at 8 hours after instillation of a single drop of 2% MK-927. The medication was well tolerated and appeared to lower intraocular pressure in a dose-dependent fashion.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0003-9950
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
108
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
65-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2404488-Adult,
pubmed-meshheading:2404488-Aged,
pubmed-meshheading:2404488-Aged, 80 and over,
pubmed-meshheading:2404488-Analysis of Variance,
pubmed-meshheading:2404488-Carbonic Anhydrase Inhibitors,
pubmed-meshheading:2404488-Dose-Response Relationship, Drug,
pubmed-meshheading:2404488-Double-Blind Method,
pubmed-meshheading:2404488-Female,
pubmed-meshheading:2404488-Glaucoma, Open-Angle,
pubmed-meshheading:2404488-Humans,
pubmed-meshheading:2404488-Intraocular Pressure,
pubmed-meshheading:2404488-Male,
pubmed-meshheading:2404488-Middle Aged,
pubmed-meshheading:2404488-Ocular Hypertension,
pubmed-meshheading:2404488-Randomized Controlled Trials as Topic,
pubmed-meshheading:2404488-Sulfonamides,
pubmed-meshheading:2404488-Thiophenes,
pubmed-meshheading:2404488-Time Factors,
pubmed-meshheading:2404488-Visual Acuity
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
MK-927: a topical carbonic anhydrase inhibitor. Dose response and duration of action.
|
| pubmed:affiliation |
Department of Ophthalmology, University of Illinois, Chicago 60612.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|