Linked Life Data

2397536

Source:http://linkedlifedata.com/resource/pubmed/id/2397536

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1990-10-16
pubmed:abstractText
Ninety-three cases of various types of human primary lung carcinomas have been studied by immunohistochemical technique and 5 cases of human primary lung adenocarcinomas by immunoelectron microscopic method with biotinized peanut lectin (PNA). The results showed that PNA staining was weak positive or negative in the normal bronchial epithelial cells which are adjacent to the carcinoma studied but strong or moderate positive in the carcinoma proper (P less than 0.05). The total positive rate of the lung carcinoma in this series is 81%. About 85% of the positive adenocarcinoma the PNA receptors were distributed along the luminal border, which corresponded with the linear electron-dense deposits on the luminal surface of the adenocarcinoma cell's membrane by immunoelectron microscopy. Squamous cell carcinoma, large cell carcinoma and small cell carcinoma, large cell carcinoma and small cell carcinoma were dominant in PNA cytoplasmic positive, while clear cell carcinoma in whole cell membrane positive. Some of the squamous cell carcinoma, large and small cell carcinoma showed microlumen by PNA staining that could not be found easily by conventional HE staining. It is suggested that these carcinomas mentioned above were poorly-differentiated adenocarcinoma or other types of carcinomas combined with adenocarcinoma. The results also assumed that the increasing of PNA receptor may be proportional to the differentiation of lung carcinoma cell. Therefore PNA receptor may be considered as a marker of carcinoma cell differentiation. It could be helpful in early diagnosis of lung carcinoma and prediction of the prognosis.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1001-0939
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-7, 126-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Immunohistochemical and immunoelectron microscopic observation of human lung carcinomas using biotinized peanut lectin (PNA)].
pubmed:affiliation
University of Medical Sciences, Guangzhou.
pubmed:publicationType
Journal Article, English Abstract