| pubmed-article:2317558 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0042974 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0042971 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C1264039 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C1441547 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C1698986 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:2317558 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:2317558 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2317558 | pubmed:dateCreated | 1990-5-4 | lld:pubmed |
| pubmed-article:2317558 | pubmed:abstractText | Endothelial cells were cultured from the umbilical veins of two neonates with type I von Willebrand disease (vWD) and compared with cells cultured in parallel from normal control umbilical veins. In both cases, cultured vWD endothelial cells contained less messenger RNA (mRNA) encoding von Willebrand factor (vWF), and constitutively secreted two- to fourfold less vWF protein than their matched controls. Regulated secretion of stored vWF induced by thrombin or phorbol-12-myristate-13-acetate (PMA) was also diminished in vWD cells. Both the mRNA and protein produced by each of these type I vWD cells appeared to be of normal size. However, despite the diminished size of the vWF storage pool, electron microscopy of endothelial cells in situ showed normal appearing vWF storage organelles (Weibel-Palade bodies). These studies show that cultured umbilical vein endothelial cells can be used to explore the molecular defects in type I and perhaps other forms of vWD, and suggest that at least some forms of type I vWD are caused by diminished mRNA transcription or subsequent translation due to a defective vWF allele. | lld:pubmed |
| pubmed-article:2317558 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2317558 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2317558 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2317558 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2317558 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2317558 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2317558 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2317558 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2317558 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2317558 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2317558 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:2317558 | pubmed:author | pubmed-author:PoberJ SJS | lld:pubmed |
| pubmed-article:2317558 | pubmed:author | pubmed-author:EwensteinB... | lld:pubmed |
| pubmed-article:2317558 | pubmed:author | pubmed-author:InbalAA | lld:pubmed |
| pubmed-article:2317558 | pubmed:author | pubmed-author:HandinR IRI | lld:pubmed |
| pubmed-article:2317558 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2317558 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2317558 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:2317558 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2317558 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2317558 | pubmed:pagination | 1466-72 | lld:pubmed |
| pubmed-article:2317558 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:meshHeading | pubmed-meshheading:2317558-... | lld:pubmed |
| pubmed-article:2317558 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2317558 | pubmed:articleTitle | Molecular studies of von Willebrand disease: reduced von Willebrand factor biosynthesis, storage, and release in endothelial cells derived from patients with type I von Willebrand disease. | lld:pubmed |
| pubmed-article:2317558 | pubmed:affiliation | Hematology Division, Brigham and Women's Hospital, Boston, MA 02115. | lld:pubmed |
| pubmed-article:2317558 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2317558 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2317558 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:2317558 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2317558 | lld:pubmed |
