Linked Life Data

2316916

Source:http://linkedlifedata.com/resource/pubmed/id/2316916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-4-19
pubmed:abstractText
Pharmacokinetic variables and metabolism of IM and IV administered ketamine (15 mg/kg of body weight) were determined in 8 swine (2 adult sows and 6 young pigs). After IM administration, maximal plasma concentration was rapidly reached, but peak concentration varied considerably, although comparison with IV data for the same swine indicated that the drug was almost completely absorbed from the musculature. After IV administration, ketamine kinetics followed a 3-term exponential decrease, indicating rapid initial distribution of the drug to highly vascular tissues including the brain, followed by redistribution into less vascular tissues, and elimination. Redistribution and elimination phases, with similar kinetics as those observed in the IV experiment, also were determined in the IM experiment. After both routes of administration, onset of anesthesia was rapid, and most swine recovered consciousness during the phase of redistribution, indicating that anesthesia is terminated by redistribution of drug from the brain into other tissues, whereas metabolism and excretion are less important for duration of anesthesia induced by ketamine. The time during which the swine resumed a lateral position (sleep time) was positively correlated with plasma ketamine concentration at onset of lateral recumbency, as well as with the area under the plasma concentration-time curve. The minimal plasma ketamine concentration for induction of immobilization was about 2 micrograms/ml. In adult sows, ketamine induced profound analgesia, which was not obtained in young pigs; this difference in potency could not be related to pharmacokinetic differences between young and adult swine.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9645
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
391-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Correlation between drug and metabolite concentrations in plasma and anesthetic action of ketamine in swine.
pubmed:affiliation
Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Federal Republic of Germany.
pubmed:publicationType
Journal Article, Comparative Study