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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1980-3-27
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pubmed:abstractText |
Suspensions of cyclic AMP sensitive cells of Dictyostelium discoideum responded to a cyclic AMP pulse with increased methylation of a protein of molecular weight about 120,000 and increased phospholipid demethylation. Protein methylation reached its peak 15-30 sec after cyclic AMP addition. Phospholipid demethylation reached its maximum within 2 min and basal levels were recovered in 3 min. S-Adenosyl-L-methionine is probably the methyl donor. In vitro addition of 0.25 mM and 25 microM S-adenosyl-L-methionine to sonicated D. discoideum cells inhibited ATP-dependent 45Ca2+ uptake by 70% and 25%, respectively. Based on these lines of evidence we propose that protein and phospholipid methylation are involved in D. discoideum chemotaxis probably by regulation of intracellular Ca2+ movements.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-133352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-14458213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-156544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-164927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-167004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-171079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-1814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-185088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-193726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-196287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-26604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-279007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-34151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-377092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-378705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-4278009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-4314777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-4366767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-5219688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/230497-5432063
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6106-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:230497-Calcium,
pubmed-meshheading:230497-Chemoreceptor Cells,
pubmed-meshheading:230497-Chemotaxis,
pubmed-meshheading:230497-Cyclic AMP,
pubmed-meshheading:230497-Dictyostelium,
pubmed-meshheading:230497-Fungal Proteins,
pubmed-meshheading:230497-Membrane Lipids,
pubmed-meshheading:230497-Methylation,
pubmed-meshheading:230497-Molecular Weight,
pubmed-meshheading:230497-Phospholipids,
pubmed-meshheading:230497-S-Adenosylmethionine
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pubmed:year |
1979
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pubmed:articleTitle |
Protein and phospholipid methylation during chemotaxis in Dictyostelium discoideum and its relationship to calcium movements.
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pubmed:publicationType |
Journal Article
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