Linked Life Data

2291006

Source:http://linkedlifedata.com/resource/pubmed/id/2291006

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1991-3-29
pubmed:abstractText
Flow cytometric cell analysis with fluorescence-labeled antibodies has become a very useful methodology for the immune phenotyping of lymphocytes. The continued evaluation of lymphocyte cell surface antigens has been of value in this respect by providing a clear picture of lymphocyte differentiation steps. Thus it is now possible to precisely identify lymphocytes of abnormal phenotype which may represent malignant cells. Detection of monotypic populations of lymphocytes represents a monoclonal expansion of a lymphocyte subset which is the hallmark of malignancy. In the case of B cell lymphoma, detection of monotypic populations rests on the finding of a monoclonal expansion of a cell type bearing one type of light chain and of heavy chain and/or one of the specific B lymphocyte differentiation antigens. The diagnosis of T cell malignancy is more difficult to establish and a diagnosis of T cell lymphoma rests on the finding of an abnormal phenotype. Thus flow cytometry in combination with histomorphologic examination is a useful technique for the more precise diagnosis of lymphomas and for the establishment of treatment protocols.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0034-1193
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-34
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Immunophenotypic analysis of non-Hodgkin's lymphomas.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston.
pubmed:publicationType
Journal Article, Comparative Study, Review