| pubmed-article:2233734 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C0205341 | lld:lifeskim |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:2233734 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:2233734 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2233734 | pubmed:dateCreated | 1990-12-5 | lld:pubmed |
| pubmed-article:2233734 | pubmed:abstractText | The hematopoietic growth factor GM-CSF (granulocyte-macrophage colony-stimulating factor) is expressed by activated but not resting T lymphocytes. Previously, we localized GM-CSF-inducible promoter activity to a 90-bp region of GM-CSF 5'-flanking sequences extending from bp -53 to +37. To more precisely identify the GM-CSF DNA sequences required for inducible promoter activity in T lymphocytes, we have performed mutagenesis within a region of GM-CSF 5'-flanking sequences (bp -57 to -24) that contains the repeated sequence CATT(A/T). Mutations that do not alter the repeated CATT(A/T) sequence do not eliminate inducible promoter activity, whereas mutation or deletion of either of the CATT(A/T) repeats eliminates all inducible promoter activity in T-cell lines and in primary human T lymphocytes. Thus, both copies of the direct repeat CATT(A/T) are required for mitogen-inducible expression of GM-CSF in T cells. | lld:pubmed |
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| pubmed-article:2233734 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2233734 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2233734 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2233734 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2233734 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:2233734 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2233734 | pubmed:author | pubmed-author:RichardsJJ | lld:pubmed |
| pubmed-article:2233734 | pubmed:author | pubmed-author:LynchMM | lld:pubmed |
| pubmed-article:2233734 | pubmed:author | pubmed-author:FraserJJ | lld:pubmed |
| pubmed-article:2233734 | pubmed:author | pubmed-author:GassonJJ | lld:pubmed |
| pubmed-article:2233734 | pubmed:author | pubmed-author:NimerSS | lld:pubmed |
| pubmed-article:2233734 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2233734 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:2233734 | pubmed:geneSymbol | hIL-5 | lld:pubmed |
| pubmed-article:2233734 | pubmed:geneSymbol | mIL-5 | lld:pubmed |
| pubmed-article:2233734 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2233734 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2233734 | pubmed:pagination | 6084-8 | lld:pubmed |
| pubmed-article:2233734 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2233734 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2233734 | pubmed:articleTitle | The repeated sequence CATT(A/T) is required for granulocyte-macrophage colony-stimulating factor promoter activity. | lld:pubmed |
| pubmed-article:2233734 | pubmed:affiliation | Department of Medicine, University of California, Los Angeles, School of Medicine. | lld:pubmed |
| pubmed-article:2233734 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2233734 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2233734 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2233734 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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