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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1990-9-26
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pubmed:databankReference |
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pubmed:abstractText |
SPT6 is an essential gene of Saccharomyces cerevisiae that appears to play a role in transcription. Mutations in the SPT6 (SSN20, CRE2) gene suppress delta insertion mutations in the 5' regions of HIS4 and LYS2 and mutations in cis- and/or trans-acting elements that are required for expression of SUC2 and ADH2. We report here that SPT6 encodes a 170-kilodalton highly charged protein with an extremely acidic amino terminus. By use of an epitope-tagged SPT6 protein, we have determined by indirect immunofluorescence that the SPT6 protein is located in the nucleus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-2407614,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-2455217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-2498648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-2834263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-2834270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-2849508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-2956925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3026915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3028647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3029564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3287180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3294100,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3312230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3474230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3514373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3526554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3530496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3545499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3547080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3548764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-3548772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-4896022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6192445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6256821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6272395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6323016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6323249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6329902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6365930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6392017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201908-6855594
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4935-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2201908-Amino Acid Sequence,
pubmed-meshheading:2201908-Base Sequence,
pubmed-meshheading:2201908-Fluorescent Antibody Technique,
pubmed-meshheading:2201908-Fungal Proteins,
pubmed-meshheading:2201908-Genes, Fungal,
pubmed-meshheading:2201908-Genotype,
pubmed-meshheading:2201908-Molecular Sequence Data,
pubmed-meshheading:2201908-Mutation,
pubmed-meshheading:2201908-Nuclear Proteins,
pubmed-meshheading:2201908-Restriction Mapping,
pubmed-meshheading:2201908-Saccharomyces cerevisiae,
pubmed-meshheading:2201908-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:2201908-Suppression, Genetic,
pubmed-meshheading:2201908-Transcription, Genetic,
pubmed-meshheading:2201908-Transcriptional Elongation Factors
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pubmed:year |
1990
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pubmed:articleTitle |
SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.
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pubmed:affiliation |
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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