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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1990-9-27
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pubmed:abstractText |
Murine models of bone marrow transplantation (BMT) are used commonly for studies of the pathogenesis and treatment of graft-versus-host disease (GVHD). We report here that the sequential measurement of the mouse acute-phase protein SAP can be used to provide a sensitive, quantitative index of the severity of GVHD. Thirty mice underwent allogeneic, and a further 30 syngeneic BMT. GVHD was assessed in vivo by clinical appearances and weight change, and post mortem by histology and calculation of splenic indices. Blood was obtained twice/week for SAP measurement and blood culture. In all mice an initial rise in SAP levels due to irradiation was followed by a return to baseline. Thereafter in syngeneic marrow recipients levels remained low. In contrast, after allogeneic BMT SAP levels rose progressively as mice developed GVHD, reaching a peak of 135 micrograms/ml prior to death, from a nadir at day 20 of 15 micrograms/ml. Mice with high splenic indices and histological evidence of severe GVHD had significantly higher SAP levels than mice with mild GVHD (P = 0.0002). Elevation in SAP levels occurred independently of bacteraemia. We conclude that in murine BMT sequential measurement of SAP provides an objective means of assessing GVHD in vivo.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-14037719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-2462501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-2643232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-2784740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-2957834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-3048486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-3138137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-3280187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-3293081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-3512716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-3554664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-3882285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-4156507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-417269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-423976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-4379352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-500121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-6372650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-6450246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-6600258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-6806378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-7046582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2201471-887146
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
329-33
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pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
pubmed-meshheading:2201471-Animals,
pubmed-meshheading:2201471-Blood,
pubmed-meshheading:2201471-Body Weight,
pubmed-meshheading:2201471-Bone Marrow Transplantation,
pubmed-meshheading:2201471-Female,
pubmed-meshheading:2201471-Graft vs Host Disease,
pubmed-meshheading:2201471-Mice,
pubmed-meshheading:2201471-Mice, Inbred C57BL,
pubmed-meshheading:2201471-Serum Amyloid P-Component,
pubmed-meshheading:2201471-Staphylococcus,
pubmed-meshheading:2201471-Transplantation, Homologous,
pubmed-meshheading:2201471-Transplantation, Isogeneic,
pubmed-meshheading:2201471-Whole-Body Irradiation
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pubmed:year |
1990
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pubmed:articleTitle |
Sequential measurement of the murine acute-phase protein serum amyloid P component (SAP) as an indicator of graft-versus-host disease following allogeneic bone marrow transplantation in mice.
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pubmed:affiliation |
Department of Bacteriology & Medicine, Hammersmith Hospital, London, England.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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