Linked Life Data

2199755

Source:http://linkedlifedata.com/resource/pubmed/id/2199755

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1990-9-12
pubmed:abstractText
Naturally-occurring Streptococcus suis type 2 meningitis affects pigs and man; experimental models of the disease have also been established in pigs and mice. A sustained, high-level bacteraemia is an important phase preceding the development of S. suis type 2 meningitis. The main cellular clearance mechanism for circulating bacteria is the resident hepatic and splenic macrophages. The interaction between various isolates of S. suis type 2 and murine macrophages was investigated to determine whether there were differences in the outcome of the interaction that would reflect observed differences in pathogenicity. Phagocytosed non-pathogenic isolates were killed whereas intracellular pathogenic organisms survived and replicated within phagosomes in the absence of anti-S. suis type 2 antibody and complement. The addition of anti-S. suis type 2 antibody and complement to macrophages containing ingested pathogenic organisms resulted in inactivation of the intracellular bacteria. Thus whilst the pathogenicity of S. suis type 2 isolates may be related to an ability to survive within macrophages, immunity to S. suis type 2 meningitis may result from anti-S. suis type 2 antibody preventing pathogenic organisms surviving within macrophages.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0882-4010
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-96
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Relationship between intracellular survival in macrophages and pathogenicity of Streptococcus suis type 2 isolates.
pubmed:affiliation
Department of Clinical Veterinary Medicine, University of Cambridge, U.K.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't