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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9797
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pubmed:dateCreated |
2011-9-29
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pubmed:abstractText |
In May 2011, an outbreak of Shiga toxin-producing enterohaemorrhagic E coli O104:H4 in northern Germany led to a high proportion of patients developing post-enteritis haemolytic uraemic syndrome and thrombotic microangiopathy that were unresponsive to therapeutic plasma exchange or complement-blocking antibody (eculizumab). Some patients needed ventilatory support due to severe neurological complications, which arose 1 week after onset of enteritis, suggesting an antibody-mediated mechanism. Therefore, we aimed to assess immunoadsorption as rescue therapy.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1474-547X
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pubmed:author |
pubmed-author:AbelPeterP,
pubmed-author:DresselAlexanderA,
pubmed-author:ErnstFriedlindeF,
pubmed-author:FelixStephan BSB,
pubmed-author:FieneMichaelM,
pubmed-author:FrieseckeSigrunS,
pubmed-author:GreinacherAndreasA,
pubmed-author:KielsteinJan TJT,
pubmed-author:LerchMarkus MMM,
pubmed-author:MayerleJuliaJ,
pubmed-author:SchifferMarioM,
pubmed-author:SchmidtBernhard M WBM,
pubmed-author:SellengKathleenK,
pubmed-author:StrackeSylviaS,
pubmed-author:WeissenbornKarinK
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
378
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1166-73
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pubmed:meshHeading |
pubmed-meshheading:21890192-Adult,
pubmed-meshheading:21890192-Enterohemorrhagic Escherichia coli,
pubmed-meshheading:21890192-Escherichia coli Infections,
pubmed-meshheading:21890192-Female,
pubmed-meshheading:21890192-Hemolytic-Uremic Syndrome,
pubmed-meshheading:21890192-Humans,
pubmed-meshheading:21890192-Immunoglobulin G,
pubmed-meshheading:21890192-Immunosorbent Techniques,
pubmed-meshheading:21890192-Male,
pubmed-meshheading:21890192-Middle Aged,
pubmed-meshheading:21890192-Nervous System Diseases,
pubmed-meshheading:21890192-Shiga-Toxigenic Escherichia coli
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pubmed:year |
2011
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pubmed:articleTitle |
Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial.
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pubmed:affiliation |
Institut für Immunologie und Transfusionsmedizin, Ernst-Moritz-Arndt-Universität, Greifswald, Germany. greinach@uni-greifswald.de
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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