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rdf:type |
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lifeskim:mentions |
umls-concept:C0009905,
umls-concept:C0014257,
umls-concept:C0025598,
umls-concept:C0028754,
umls-concept:C0032460,
umls-concept:C0043210,
umls-concept:C0087111,
umls-concept:C0205195,
umls-concept:C0311400,
umls-concept:C0497406,
umls-concept:C0542341,
umls-concept:C1280500,
umls-concept:C1521761
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pubmed:issue |
2
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pubmed:dateCreated |
2011-7-25
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pubmed:databankReference |
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pubmed:abstractText |
In this randomized, double-blind, placebo-controlled study, 19 overweight women with polycystic ovary syndrome were randomized to a 3-month course of either metformin plus combined hormonal oral contraceptive (OC) (n = 9) or OC plus matched placebo (n = 10). After 3 months, both treatments had similar effects on androgen levels, lipid profile, insulin sensitivity, and serum inflammatory markers, but flow-mediated dilatation increased by 69.0% in the metformin plus OC group while it remained unchanged in the OC group. CLINICAL TRIAL REGISTRATION NO: NCT00682890.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Combined,
http://linkedlifedata.com/resource/pubmed/chemical/Contraceptives, Oral, Hormonal,
http://linkedlifedata.com/resource/pubmed/chemical/Ethinyl Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadal Steroid Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Metformin,
http://linkedlifedata.com/resource/pubmed/chemical/Norgestrel,
http://linkedlifedata.com/resource/pubmed/chemical/norgestimate, ethinyl estradiol...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1556-5653
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
501-504.e2
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:21733508-Analysis of Variance,
pubmed-meshheading:21733508-Biological Markers,
pubmed-meshheading:21733508-Blood Glucose,
pubmed-meshheading:21733508-Contraceptives, Oral, Combined,
pubmed-meshheading:21733508-Contraceptives, Oral, Hormonal,
pubmed-meshheading:21733508-Double-Blind Method,
pubmed-meshheading:21733508-Drug Therapy, Combination,
pubmed-meshheading:21733508-Endothelium, Vascular,
pubmed-meshheading:21733508-Ethinyl Estradiol,
pubmed-meshheading:21733508-Female,
pubmed-meshheading:21733508-Gonadal Steroid Hormones,
pubmed-meshheading:21733508-Humans,
pubmed-meshheading:21733508-Hypoglycemic Agents,
pubmed-meshheading:21733508-Inflammation Mediators,
pubmed-meshheading:21733508-Insulin,
pubmed-meshheading:21733508-Insulin Resistance,
pubmed-meshheading:21733508-Lipids,
pubmed-meshheading:21733508-Metformin,
pubmed-meshheading:21733508-Norgestrel,
pubmed-meshheading:21733508-Obesity,
pubmed-meshheading:21733508-Overweight,
pubmed-meshheading:21733508-Placebo Effect,
pubmed-meshheading:21733508-Polycystic Ovary Syndrome,
pubmed-meshheading:21733508-Time Factors,
pubmed-meshheading:21733508-Treatment Outcome,
pubmed-meshheading:21733508-Vasodilation,
pubmed-meshheading:21733508-Virginia
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pubmed:year |
2011
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pubmed:articleTitle |
Effect of combined metformin and oral contraceptive therapy on metabolic factors and endothelial function in overweight and obese women with polycystic ovary syndrome.
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pubmed:affiliation |
Department of Internal Medicine, School of Medicine, Medical College of Virginia Hospitals, Virginia Commonwealth University, Richmond, Virginia, USA. paessah@comcast.net
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, N.I.H., Extramural
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