Source:http://linkedlifedata.com/resource/pubmed/id/21700414
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2011-7-11
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pubmed:abstractText |
Perturbed apoptosis due to missense alterations in candidate tumor suppressor gene Death receptor 4 (DR4) and in caspases (Casp) lead to deregulated cell proliferation and cancer predisposition. Some data indicate that normal variations within the sequence of apoptotic genes may lead to suboptimal apoptotic capacity and therefore increased cancer risk. To test our proposal we examined whether six single nucleotide polymorphisms (SNPs) of the DR4 and Casp3, 5 genes contrive the risk of bladder cancer (BC) in a North Indian population.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1532-2157
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pubmed:author | |
pubmed:copyrightInfo |
Copyright © 2011 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
727-33
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pubmed:meshHeading |
pubmed-meshheading:21700414-Aged,
pubmed-meshheading:21700414-Case-Control Studies,
pubmed-meshheading:21700414-Caspase 3,
pubmed-meshheading:21700414-Caspases,
pubmed-meshheading:21700414-Female,
pubmed-meshheading:21700414-Genetic Predisposition to Disease,
pubmed-meshheading:21700414-Genotype,
pubmed-meshheading:21700414-Humans,
pubmed-meshheading:21700414-India,
pubmed-meshheading:21700414-Male,
pubmed-meshheading:21700414-Middle Aged,
pubmed-meshheading:21700414-Polymorphism, Single Nucleotide,
pubmed-meshheading:21700414-Receptors, TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:21700414-Smoking,
pubmed-meshheading:21700414-Urinary Bladder Neoplasms
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pubmed:year |
2011
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pubmed:articleTitle |
Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians.
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pubmed:affiliation |
Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, Uttar Pradesh, India. ramamittal@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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