Linked Life Data

216969

Source:http://linkedlifedata.com/resource/pubmed/id/216969

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1979-4-25
pubmed:abstractText
Somatic cell hybrids were prepared by fusing malignant mouse melanoma cells with diploid human lymphocytes and fibroblasts in the presence of inactivated Sendai virus. Clones of hybrid cells differed from one another with respect to the number of chromosomes. In particular, human chromosomes were preferentially lost and mouse chromosomes retained. Hybrid clones containing a range of human chromosomes were selected and assayed for tumorigenicity in nude mice, and the presence or absence of specific human chromosomes was correlated with malignancy. Both human lymphocytes and human fibroblasts suppressed the malignancy of mouse melanoma cells. In most cases, suppression of malignancy was complete; in a few cases, tumours developed but the tumorigenicity of these hybrids was considerably less than that of the parent melanoma cells. Chromosome analyses failed to localize the suppressive effect to a specific chromosome.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-3025
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
343-50
pubmed:dateRevised
2006-10-31
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Suppression of malignancy in mouse-man hybrid cells.
pubmed:publicationType
Journal Article