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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2011-7-1
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pubmed:abstractText |
Various types of radiation effects in mammalian cells have been studied with the aim to predict the radiosensitivity of tumours and normal tissues, e.g. DNA double strand breaks (DSB), chromosome aberrations and cell reproductive inactivation. However, variation in correlations with clinical results has reduced general application. An additional type of information is required for the increasing application of high-LET radiation in cancer therapy: the Relative Biological Effectiveness (RBE) for effects in tumours and normal tissues. Relevant information on RBE values might be derived from studies on cells in culture.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1748-717X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
64
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pubmed:meshHeading |
pubmed-meshheading:21651780-Alpha Particles,
pubmed-meshheading:21651780-Americium,
pubmed-meshheading:21651780-Carcinoma, Squamous Cell,
pubmed-meshheading:21651780-Cell Line, Tumor,
pubmed-meshheading:21651780-Cell Proliferation,
pubmed-meshheading:21651780-Cell Survival,
pubmed-meshheading:21651780-Cesium Radioisotopes,
pubmed-meshheading:21651780-Chromosome Aberrations,
pubmed-meshheading:21651780-Chromosomes,
pubmed-meshheading:21651780-DNA,
pubmed-meshheading:21651780-DNA Breaks, Double-Stranded,
pubmed-meshheading:21651780-DNA Repair,
pubmed-meshheading:21651780-Dose-Response Relationship, Radiation,
pubmed-meshheading:21651780-Humans,
pubmed-meshheading:21651780-Lung Neoplasms,
pubmed-meshheading:21651780-Radiotherapy
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pubmed:year |
2011
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pubmed:articleTitle |
Comparison of RBE values of high-LET ?-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death.
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pubmed:affiliation |
Department of Radiation Oncology, Laboratory for Experimental Oncology and Radiobiology, Centre for Experimental Molecular Medicine, University of Amsterdam, Amsterdam, The Netherlands. n.a.franken@amc.uva.nl
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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