| pubmed-article:21622145 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21622145 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:21622145 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:21622145 | lifeskim:mentions | umls-concept:C0018207 | lld:lifeskim |
| pubmed-article:21622145 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:21622145 | lifeskim:mentions | umls-concept:C0733758 | lld:lifeskim |
| pubmed-article:21622145 | lifeskim:mentions | umls-concept:C0040135 | lld:lifeskim |
| pubmed-article:21622145 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:21622145 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21622145 | pubmed:dateCreated | 2011-5-30 | lld:pubmed |
| pubmed-article:21622145 | pubmed:abstractText | Thyroid hormone (TH) is important for normal reproductive function. Our previous studies indicate that FSH increases preantral follicle growth in vitro, a response markedly enhanced by triiodothyronine (T3). However, the nature of this hormonal interaction is poorly understood. The objective of this study was to determine if and how T3 modulate FSH-induced expression and actions of granulosa cell intracellular survival and death intermediates. We investigated the possible involvement of Src and PI3K/Akt pathway in the regulation of granulosa cell survival. We demonstrated that, while ineffective alone (0.1-100 nM), T3 markedly enhanced FSH (100 ng/ml)-induced granulosa cell phospho-Src and phospho-Akt contents and Xiap expression in vitro. The effects of T3 were concentration-dependent, with maximal responses at 1.0 nM. FSH alone decreased Fas Ligand (FasL) content irrespective of the presence of T3. Co-treatment of cell with T3 and FSH decreased Fas content, although neither hormone alone elicited a significant response. Taken together, the present study demonstrates that T3 potentiates the cell survival action of FSH through Src- and PI3K-mediated Xiap up-regulation and decreased Fas and FasL expression. | lld:pubmed |
| pubmed-article:21622145 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622145 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21622145 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622145 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21622145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622145 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622145 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21622145 | pubmed:issn | 1945-0508 | lld:pubmed |
| pubmed-article:21622145 | pubmed:author | pubmed-author:ZhangChengC | lld:pubmed |
| pubmed-article:21622145 | pubmed:author | pubmed-author:XiaGuoliangG | lld:pubmed |
| pubmed-article:21622145 | pubmed:author | pubmed-author:TsangBenjamin... | lld:pubmed |
| pubmed-article:21622145 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21622145 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:21622145 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21622145 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21622145 | pubmed:pagination | 1401-13 | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:meshHeading | pubmed-meshheading:21622145... | lld:pubmed |
| pubmed-article:21622145 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21622145 | pubmed:articleTitle | Interactions of thyroid hormone and FSH in the regulation of rat granulosa cell apoptosis. | lld:pubmed |
| pubmed-article:21622145 | pubmed:affiliation | State Key Laboratory for Agro-Biotechnology, College of Biological Science, China Agricultural University, Beijing, Peoples' Republic of China. | lld:pubmed |
| pubmed-article:21622145 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21622145 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
