| pubmed-article:2162053 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2162053 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2162053 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:2162053 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:2162053 | lifeskim:mentions | umls-concept:C2323499 | lld:lifeskim |
| pubmed-article:2162053 | lifeskim:mentions | umls-concept:C0334094 | lld:lifeskim |
| pubmed-article:2162053 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:2162053 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:2162053 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:2162053 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2162053 | pubmed:dateCreated | 1990-7-19 | lld:pubmed |
| pubmed-article:2162053 | pubmed:abstractText | Retrovirally mediated introduction of a cDNA encoding a placenta-derived low-affinity receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF) into murine FDC-P1 hemopoietic cells allowed these cells to proliferate when stimulated by human GM-CSF. The expressed human receptors on cloned lines were of low affinity (Kd = 4-6 nM), were internalized, and did not interact with endogenous GM-CSF receptors. Concentrations of human GM-CSF of 6.5-13 nM were required to stimulate 50% maximal colony formation versus a concentration of murine GM-CSF of 6 pM; this difference is comparable with the difference in relative affinities of the human and murine receptors for their respective ligands. If maintained in murine GM-CSF, cells able to bind or respond to human GM-CSF were rapidly lost due to transcriptional inactivation of the inserted cDNA. The observations indicate that low-affinity receptors for human GM-CSF can deliver a proliferative signal in appropriate cells and that the signaling mechanisms are not species-specific. | lld:pubmed |
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| pubmed-article:2162053 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:2162053 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2162053 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2162053 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2162053 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2162053 | pubmed:author | pubmed-author:NicolaN ANA | lld:pubmed |
| pubmed-article:2162053 | pubmed:author | pubmed-author:MetcalfDD | lld:pubmed |
| pubmed-article:2162053 | pubmed:author | pubmed-author:GoughN MNM | lld:pubmed |
| pubmed-article:2162053 | pubmed:author | pubmed-author:GearingD PDP | lld:pubmed |
| pubmed-article:2162053 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2162053 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:2162053 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2162053 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2162053 | pubmed:pagination | 4670-4 | lld:pubmed |
| pubmed-article:2162053 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2162053 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2162053 | pubmed:articleTitle | Low-affinity placenta-derived receptors for human granulocyte-macrophage colony-stimulating factor can deliver a proliferative signal to murine hemopoietic cells. | lld:pubmed |
| pubmed-article:2162053 | pubmed:affiliation | Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. | lld:pubmed |
| pubmed-article:2162053 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2162053 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2162053 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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