|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0030705,
umls-concept:C0035397,
umls-concept:C0087111,
umls-concept:C0181586,
umls-concept:C0205146,
umls-concept:C0205178,
umls-concept:C0299583,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0443252,
umls-concept:C1744681
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2011-8-5
|
|
pubmed:abstractText |
Mutations that lead to congenital leptin deficiency cause severe obesity, hyperphagia, and impaired satiety due to malfunctions of peripheral and brain-related mechanisms.
|
|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1945-7197
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
96
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
E1283-7
|
|
pubmed:meshHeading |
pubmed-meshheading:21593110-Acute Disease,
pubmed-meshheading:21593110-Adolescent,
pubmed-meshheading:21593110-Amygdala,
pubmed-meshheading:21593110-Brain,
pubmed-meshheading:21593110-Feeding Behavior,
pubmed-meshheading:21593110-Female,
pubmed-meshheading:21593110-Frontal Lobe,
pubmed-meshheading:21593110-Homeostasis,
pubmed-meshheading:21593110-Humans,
pubmed-meshheading:21593110-Hyperphagia,
pubmed-meshheading:21593110-Leptin,
pubmed-meshheading:21593110-Magnetic Resonance Imaging,
pubmed-meshheading:21593110-Obesity,
pubmed-meshheading:21593110-Reward,
pubmed-meshheading:21593110-Satiety Response,
pubmed-meshheading:21593110-Substantia Nigra,
pubmed-meshheading:21593110-Time,
pubmed-meshheading:21593110-Ventral Tegmental Area
|
|
pubmed:year |
2011
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|
pubmed:articleTitle |
Leptin therapy in a congenital leptin-deficient patient leads to acute and long-term changes in homeostatic, reward, and food-related brain areas.
|
|
pubmed:affiliation |
MEG Center, University of Tübingen, Tübingen, Germany. sabine.frank@med.uni-tuebingen.de
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|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|
