| pubmed-article:21546313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21546313 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21546313 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:21546313 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21546313 | lifeskim:mentions | umls-concept:C0014072 | lld:lifeskim |
| pubmed-article:21546313 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:21546313 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:21546313 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21546313 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21546313 | pubmed:dateCreated | 2011-8-22 | lld:pubmed |
| pubmed-article:21546313 | pubmed:abstractText | Antigen-immunoglobulin fusion protein expressing B cells have been shown as excellent tolerogenic antigen-presenting cells in multiple disease models. Using efficient protein transduction by fusion with a HIV TAT protein transduction domain, we herein tested the TAT-fusion protein transduced B cells for their effects in antigen-specific tolerance induction in two animal models, experimental autoimmune encephalomyelitis (EAE) and type 1 diabetes. We demonstrated that transfer of TAT-MOG35-55 (myelin oligodendrocyte glycoprotein)-Ig 'transduced B cells' 10 days after EAE induction significantly protected mice from disease. Similarly, the onset of disease was delayed when NOD mice received insulin specific TAT-B9-23-B cells. Surprisingly, no protection against EAE was observed in a prophylactic protocol when transduced B cells were given before disease induction. Moreover, TAT-ovalbumin transduced cells were tolerogenic in primed but not naïve mice. Our results suggest that TAT-fusion protein transduced B cells were tolerogenic in antigen primed recipients, a condition clinically relevant to autoimmune diseases. | lld:pubmed |
| pubmed-article:21546313 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21546313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21546313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21546313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21546313 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:21546313 | pubmed:issn | 1521-7035 | lld:pubmed |
| pubmed-article:21546313 | pubmed:author | pubmed-author:RézGG | lld:pubmed |
| pubmed-article:21546313 | pubmed:author | pubmed-author:XuZ CZC | lld:pubmed |
| pubmed-article:21546313 | pubmed:author | pubmed-author:ScottDavid... | lld:pubmed |
| pubmed-article:21546313 | pubmed:author | pubmed-author:ZhangAi-HongA... | lld:pubmed |
| pubmed-article:21546313 | pubmed:author | pubmed-author:SkupskyJonath... | lld:pubmed |
| pubmed-article:21546313 | pubmed:author | pubmed-author:Owusu-Boaitey... | lld:pubmed |
| pubmed-article:21546313 | pubmed:copyrightInfo | Published by Elsevier Inc. | lld:pubmed |
| pubmed-article:21546313 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21546313 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:21546313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21546313 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21546313 | pubmed:pagination | 260-7 | lld:pubmed |
| pubmed-article:21546313 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:21546313 | pubmed:meshHeading | pubmed-meshheading:21546313... | lld:pubmed |
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| pubmed-article:21546313 | pubmed:meshHeading | pubmed-meshheading:21546313... | lld:pubmed |
| pubmed-article:21546313 | pubmed:meshHeading | pubmed-meshheading:21546313... | lld:pubmed |
| pubmed-article:21546313 | pubmed:meshHeading | pubmed-meshheading:21546313... | lld:pubmed |
| pubmed-article:21546313 | pubmed:meshHeading | pubmed-meshheading:21546313... | lld:pubmed |
| pubmed-article:21546313 | pubmed:meshHeading | pubmed-meshheading:21546313... | lld:pubmed |
| pubmed-article:21546313 | pubmed:meshHeading | pubmed-meshheading:21546313... | lld:pubmed |
| pubmed-article:21546313 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21546313 | pubmed:articleTitle | B cells "transduced" with TAT-fusion proteins can induce tolerance and protect mice from diabetes and EAE. | lld:pubmed |
| pubmed-article:21546313 | pubmed:affiliation | Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA. | lld:pubmed |
| pubmed-article:21546313 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21546313 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21546313 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21546313 | lld:pubmed |
