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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2011-5-3
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pubmed:abstractText |
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. The alveolar subtype of rhabdomyosarcoma (ARMS) is a paradigm for refractory and incurable solid tumors because more than half of the children at diagnosis have either regional lymph node or distant metastases. These studies follow our previous observation that Interleukin-4 receptor ? (IL-4R?) is upregulated in both human and murine ARMS, and that the IL-4R signaling pathway may be a target for abrogating tumor progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AbrahamJinuJ,
pubmed-author:AslamMohammed ImranMI,
pubmed-author:GuttridgeDenis CDC,
pubmed-author:HosoyamaTohruT,
pubmed-author:KellerCharlesC,
pubmed-author:MichalekJoel EJE,
pubmed-author:NelonLaura DLD,
pubmed-author:NishijoKoichiK,
pubmed-author:PrajapatiSuresh ISI,
pubmed-author:RubinBrian PBP,
pubmed-author:ZarzabalLee AnnLA
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pubmed:copyrightInfo |
©2011 AACR.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2757-66
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pubmed:meshHeading |
pubmed-meshheading:21536546-Animals,
pubmed-meshheading:21536546-Cell Dedifferentiation,
pubmed-meshheading:21536546-Cell Transformation, Neoplastic,
pubmed-meshheading:21536546-Cells, Cultured,
pubmed-meshheading:21536546-Disease Models, Animal,
pubmed-meshheading:21536546-Genes, p53,
pubmed-meshheading:21536546-Humans,
pubmed-meshheading:21536546-Mice,
pubmed-meshheading:21536546-Mice, Transgenic,
pubmed-meshheading:21536546-Mitogens,
pubmed-meshheading:21536546-Muscle Neoplasms,
pubmed-meshheading:21536546-Myogenic Regulatory Factors,
pubmed-meshheading:21536546-Neoplasm Metastasis,
pubmed-meshheading:21536546-Paired Box Transcription Factors,
pubmed-meshheading:21536546-Receptors, Interleukin-4,
pubmed-meshheading:21536546-Rhabdomyosarcoma,
pubmed-meshheading:21536546-Signal Transduction
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pubmed:year |
2011
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pubmed:articleTitle |
IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma.
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pubmed:affiliation |
Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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