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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0020792,
umls-concept:C0024204,
umls-concept:C0024623,
umls-concept:C0033684,
umls-concept:C0035647,
umls-concept:C0036525,
umls-concept:C0334227,
umls-concept:C1171362,
umls-concept:C1269955,
umls-concept:C1515670,
umls-concept:C1522484,
umls-concept:C2699153
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pubmed:issue |
6
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pubmed:dateCreated |
2011-6-20
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pubmed:abstractText |
In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0219-1032
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
563-71
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pubmed:meshHeading |
pubmed-meshheading:21533548-Adenocarcinoma, Scirrhous,
pubmed-meshheading:21533548-Adult,
pubmed-meshheading:21533548-Aged,
pubmed-meshheading:21533548-Aged, 80 and over,
pubmed-meshheading:21533548-Amino Acid Sequence,
pubmed-meshheading:21533548-Aspartate Aminotransferases,
pubmed-meshheading:21533548-Cell Line, Tumor,
pubmed-meshheading:21533548-DNA-Binding Proteins,
pubmed-meshheading:21533548-Electrophoresis, Gel, Two-Dimensional,
pubmed-meshheading:21533548-Female,
pubmed-meshheading:21533548-Humans,
pubmed-meshheading:21533548-Lymphatic Metastasis,
pubmed-meshheading:21533548-Male,
pubmed-meshheading:21533548-Middle Aged,
pubmed-meshheading:21533548-Mitochondrial Proton-Translocating ATPases,
pubmed-meshheading:21533548-Molecular Sequence Data,
pubmed-meshheading:21533548-Neoplasm Invasiveness,
pubmed-meshheading:21533548-Proteins,
pubmed-meshheading:21533548-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:21533548-Stomach Neoplasms,
pubmed-meshheading:21533548-Transcription Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes.
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pubmed:affiliation |
Department of Biotechnology, Seoul Women's University, Seoul, 139-774, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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