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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2011-6-27
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pubmed:abstractText |
Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/C06 RR016499,
http://linkedlifedata.com/resource/pubmed/grant/K24 HD001346-01,
http://linkedlifedata.com/resource/pubmed/grant/K24-HD01346,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR00048,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR02635,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR10732,
http://linkedlifedata.com/resource/pubmed/grant/M01-RR00425,
http://linkedlifedata.com/resource/pubmed/grant/P50 HD044405-10,
http://linkedlifedata.com/resource/pubmed/grant/P50 HD44405,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK079888-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 HD029364-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HD029364-15,
http://linkedlifedata.com/resource/pubmed/grant/R01-DK79888,
http://linkedlifedata.com/resource/pubmed/grant/R01-HD29364,
http://linkedlifedata.com/resource/pubmed/grant/RR10732,
http://linkedlifedata.com/resource/pubmed/grant/U54 HD034449-11,
http://linkedlifedata.com/resource/pubmed/grant/U54 HD34449,
http://linkedlifedata.com/resource/pubmed/grant/U54HD034449
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1556-5653
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pubmed:author |
pubmed-author:AnkenerWendyW,
pubmed-author:AzzizRicardoR,
pubmed-author:ChuaAngelaA,
pubmed-author:DunaifAndreaA,
pubmed-author:EwensKathryn GKG,
pubmed-author:GoodarziMark OMO,
pubmed-author:JonesMichelle RMR,
pubmed-author:LegroRichard SRS,
pubmed-author:SpielmanRichard SRS,
pubmed-author:StewartDouglas RDR,
pubmed-author:StraussJerome FJF3rd,
pubmed-author:UrbanekMargritM
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pubmed:copyrightInfo |
Copyright © 2011 American Society for Reproductive Medicine. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2538-41.e1-6
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21444075-Case-Control Studies,
pubmed-meshheading:21444075-Diabetes Mellitus, Type 2,
pubmed-meshheading:21444075-Female,
pubmed-meshheading:21444075-Gene Frequency,
pubmed-meshheading:21444075-Genetic Predisposition to Disease,
pubmed-meshheading:21444075-Genome-Wide Association Study,
pubmed-meshheading:21444075-Haplotypes,
pubmed-meshheading:21444075-Humans,
pubmed-meshheading:21444075-Insulin-Secreting Cells,
pubmed-meshheading:21444075-Linkage Disequilibrium,
pubmed-meshheading:21444075-Phenotype,
pubmed-meshheading:21444075-Polycystic Ovary Syndrome,
pubmed-meshheading:21444075-Polymorphism, Single Nucleotide,
pubmed-meshheading:21444075-Risk Assessment,
pubmed-meshheading:21444075-Risk Factors,
pubmed-meshheading:21444075-United States
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pubmed:year |
2011
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pubmed:articleTitle |
Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.
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pubmed:affiliation |
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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