Linked Life Data

21438664

Source:http://linkedlifedata.com/resource/pubmed/id/21438664

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2011-7-28
pubmed:abstractText
The antiproliferative activity of 2-(3,5-Dihydroxyphenyl)-6-hydroxybenzothiazole (DHB) is reported here. DHB inhibits the growth of human colon cancer HCT-15 with a 50% cell growth inhibition value of 23??M and breast cancer MCF-7 with a 50% cell growth inhibition value of 41??M in a dose/time dependent manner by using sulforhodamine B assay. Cell cycle analysis by flow cytometry showed that DHB-induced growth arrest could be associated with apoptosis in both cell lines. Moreover, suppression of clonogenic activity occurs after exposure to DHB at a concentration of 25??M for HCT-15 and of 40??M for MCF-7.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1557-7430
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
617-21
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Antiproliferative activity and cell cycle analysis of 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole on MCF-7 breast and HCT-15 colon cancer cell lines.
pubmed:affiliation
Department of Chemistry, Islamic Azad University, Neyshabur Branch, Neyshabur, Iran. m.rajabi.s@gmail.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't