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pubmed-article:21419609pubmed:abstractTextKidney stones are a common problem for which inadequate prevention exists. We recruited ten recurrent kidney stone formers with documented calcium oxalate stones into a two phased study to assess safety and effectiveness of Cystone(®), an herbal treatment for prevention of kidney stones. The first phase was a randomized double-blinded 12 week cross over study assessing the effect of Cystone(®) vs. placebo on urinary supersaturation. The second phase was an open label one year study of Cystone(®) to determine if renal stone burden decreased, as assessed by quantitative and subjective assessment of CT. Results revealed no statistically significant effect of Cystone(®) on urinary composition short (6 weeks) or long (52 weeks) term. Average renal stone burden increased rather than decreased on Cystone(®). Therefore, this study does not support the efficacy of Cystone(®) to treat calcium oxalate stone formers. Future studies will be needed to assess effects on stone passage, or on other stone types.lld:pubmed
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pubmed-article:21419609pubmed:authorpubmed-author:EricksonS BSBlld:pubmed
pubmed-article:21419609pubmed:authorpubmed-author:VrtiskaT JTJlld:pubmed
pubmed-article:21419609pubmed:authorpubmed-author:LieskeJ CJClld:pubmed
pubmed-article:21419609pubmed:copyrightInfoCopyright © 2011 Elsevier GmbH. All rights reserved.lld:pubmed
pubmed-article:21419609pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21419609pubmed:day15lld:pubmed
pubmed-article:21419609pubmed:volume18lld:pubmed
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pubmed-article:21419609pubmed:year2011lld:pubmed
pubmed-article:21419609pubmed:articleTitleEffect of Cystone® on urinary composition and stone formation over a one year period.lld:pubmed
pubmed-article:21419609pubmed:affiliationDivision of Nephrology & Hypertension, Ma-E19, Mayo Clinic, Rochester, MN 55905, USA. erickson.stephen@mayo.edulld:pubmed
pubmed-article:21419609pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21419609pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:21419609pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:21419609pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed