rdf:type |
|
lifeskim:mentions |
umls-concept:C0007610,
umls-concept:C0024660,
umls-concept:C0205147,
umls-concept:C0392752,
umls-concept:C1158740,
umls-concept:C1514873,
umls-concept:C1521761,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C2699782
|
pubmed:issue |
6257
|
pubmed:dateCreated |
1990-3-5
|
pubmed:abstractText |
A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0028-0836
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
343
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
437-41
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:2137203-Animals,
pubmed-meshheading:2137203-Antibodies, Monoclonal,
pubmed-meshheading:2137203-Antigens,
pubmed-meshheading:2137203-Cell Nucleus,
pubmed-meshheading:2137203-Fluorescent Antibody Technique,
pubmed-meshheading:2137203-Immunosorbent Techniques,
pubmed-meshheading:2137203-Microscopy, Electron,
pubmed-meshheading:2137203-Nuclear Proteins,
pubmed-meshheading:2137203-RNA, Messenger,
pubmed-meshheading:2137203-RNA Precursors,
pubmed-meshheading:2137203-RNA Splicing,
pubmed-meshheading:2137203-Ribonucleoproteins,
pubmed-meshheading:2137203-Ribonucleoproteins, Small Nuclear
|
pubmed:year |
1990
|
pubmed:articleTitle |
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus.
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|