| pubmed-article:21330015 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21330015 | lifeskim:mentions | umls-concept:C0003392 | lld:lifeskim |
| pubmed-article:21330015 | lifeskim:mentions | umls-concept:C0068707 | lld:lifeskim |
| pubmed-article:21330015 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:21330015 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:21330015 | lifeskim:mentions | umls-concept:C0043309 | lld:lifeskim |
| pubmed-article:21330015 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:21330015 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:21330015 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:21330015 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21330015 | pubmed:dateCreated | 2011-3-4 | lld:pubmed |
| pubmed-article:21330015 | pubmed:abstractText | NAmPRTase (PBEF/Visfatin) plays a pivotal role in the salvage pathway of NAD(+) biosynthesis. NAmPRTase has been an attractive target for anti-cancer agents that induce apoptosis of tumor cells via a declining plasma NAD(+) level. In this report, a series of structural analogs of FK866 (1), a known NAmPRTase inhibitor, was synthesized and tested for inhibitory activities against the proliferation of cancer cells and human NAmPRTase. Among them, compound 7 showed similar anti-cancer and enzyme inhibitory activities to compound 1. Further investigation of compound 7 with X-ray analysis revealed a co-crystal structure in complex with human NAmPRTase, suggesting that Asp219 in the active site of the enzyme could contribute to an additional interaction with the pyrrole nitrogen of compound 7. | lld:pubmed |
| pubmed-article:21330015 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21330015 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330015 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21330015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330015 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330015 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21330015 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21330015 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:21330015 | pubmed:author | pubmed-author:ImázMM | lld:pubmed |
| pubmed-article:21330015 | pubmed:author | pubmed-author:KoHyojinH | lld:pubmed |
| pubmed-article:21330015 | pubmed:author | pubmed-author:EomSoo HyunSH | lld:pubmed |
| pubmed-article:21330015 | pubmed:author | pubmed-author:KimYong-ChulY... | lld:pubmed |
| pubmed-article:21330015 | pubmed:author | pubmed-author:LeeSang-KookS... | lld:pubmed |
| pubmed-article:21330015 | pubmed:author | pubmed-author:BaeMan-HoMH | lld:pubmed |
| pubmed-article:21330015 | pubmed:author | pubmed-author:YounHyung-Seo... | lld:pubmed |
| pubmed-article:21330015 | pubmed:author | pubmed-author:YouHyunH | lld:pubmed |
| pubmed-article:21330015 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Masson SAS. All rights reserved. | lld:pubmed |
| pubmed-article:21330015 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21330015 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:21330015 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21330015 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21330015 | pubmed:pagination | 1153-64 | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:meshHeading | pubmed-meshheading:21330015... | lld:pubmed |
| pubmed-article:21330015 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21330015 | pubmed:articleTitle | Design, synthesis and X-ray crystallographic study of NAmPRTase inhibitors as anti-cancer agents. | lld:pubmed |
| pubmed-article:21330015 | pubmed:affiliation | School of Life Science, Gwangju Institute of Science and Technology, Gwangju 500-712, Republic of Korea. | lld:pubmed |
| pubmed-article:21330015 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21330015 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21330015 | lld:chembl |
