Linked Life Data

21297274

Source:http://linkedlifedata.com/resource/pubmed/id/21297274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-4-12
pubmed:abstractText
Appropriate treatment of dementia requires biomarkers that provide an exact and differential diagnosis. We recently presented differentially expressed amyloid-? (A?) peptide patterns in cerebrospinal fluid (CSF) as biomarker candidates for neurochemical diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). The objective of the present study was to investigate CSF A? peptide patterns in both neuropathologically and clinically defined diagnostic groups of AD and DLB. Using the quantitative A?-SDS-PAGE/immunoblot, we analyzed CSF samples of neuropathologically defined patients with AD (definite AD, dAD; n = 11) and DLB (definite, dDLB; n = 12). We compared absolute and relative quantities of CSF A?-peptides with a larger cohort of clinically diagnosed patients with probable AD (pAD; n = 71), probable DLB (pDLB; n = 32), and non-demented controls (NDC; n = 71). Each neuropathologically and clinically defined diagnostic group showed a similar relative distribution of CSF A?-peptides (A?(1-X%)). A?(1-42%) was lowered in dAD compared to NDC (p = 1.6 × 10??, but did not differ between dAD and pAD. A?(1-40ox%) was elevated in dDLB as compared to NDC (p = 1.8 × 10??, but did not differ between dDLB and pDLB. Thus, we were able to confirm previous results on A? peptide patterns in neuropathologically characterized patients with AD and DLB. Our results underline the usefulness of the CSF A?(1-42%) and A?(1-40ox%) as diagnostic biomarkers for AD and DLB, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1875-8908
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
383-91
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
CSF amyloid-? peptides in neuropathologically diagnosed dementia with Lewy bodies and Alzheimer's disease.
pubmed:affiliation
Paracelsus-Elena Klinik Kassel and Department of Neurology, Georg-August University, Göttingen, Germany. brit.mollenhauer@pk-mx.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't