|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0030685,
umls-concept:C0031327,
umls-concept:C0032854,
umls-concept:C0034656,
umls-concept:C0057223,
umls-concept:C0078569,
umls-concept:C0150097,
umls-concept:C0205231,
umls-concept:C0231449,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1332830,
umls-concept:C1561558,
umls-concept:C1880288,
umls-concept:C1963578
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2011-2-3
|
|
pubmed:abstractText |
Genetically driven variations in the level of cytochrome P450 (CYP) 2D6 metabolic activity have been shown to significantly affect the pharmacokinetic behaviour of medications that are substrates of this enzyme.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1173-2563
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
31
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
155-67
|
|
pubmed:meshHeading |
pubmed-meshheading:21288052-Adult,
pubmed-meshheading:21288052-Area Under Curve,
pubmed-meshheading:21288052-Chromatography, Liquid,
pubmed-meshheading:21288052-Cross-Over Studies,
pubmed-meshheading:21288052-Cyclohexanols,
pubmed-meshheading:21288052-Cytochrome P-450 CYP2D6,
pubmed-meshheading:21288052-Delayed-Action Preparations,
pubmed-meshheading:21288052-Female,
pubmed-meshheading:21288052-Genotype,
pubmed-meshheading:21288052-Humans,
pubmed-meshheading:21288052-Male,
pubmed-meshheading:21288052-Polymorphism, Genetic,
pubmed-meshheading:21288052-Serotonin Uptake Inhibitors,
pubmed-meshheading:21288052-Tandem Mass Spectrometry,
pubmed-meshheading:21288052-Young Adult
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|
pubmed:year |
2011
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|
pubmed:articleTitle |
Pharmacokinetics of venlafaxine extended release 75 ?mg and desvenlafaxine 50? mg in healthy CYP2D6 extensive and poor metabolizers: a randomized, open-label, two-period, parallel-group, crossover study.
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pubmed:affiliation |
Pfizer Inc, formerly Wyeth Research, Collegeville, Pennsylvania, USA. Alice.Nichols@pfizer.com
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
