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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2011-3-29
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pubmed:abstractText |
Dermatofibrosarcoma protuberans (DFSP) was recently proposed to originate from a nestin-positive stem cell. In postnatal skin, nestin and another embryonic stem cell marker, SOX2, display a similar expression pattern with immunoreactivity in the hair follicle papilla and scattered cells of the perifollicular connective tissue sheath. The distribution pattern differs only in early embryogenesis, when nestin but not SOX2 is also expressed throughout the entire interfollicular dermis. We speculated that DFSP would not only be nestin-positive but also SOX2-positive.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1600-0560
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 John Wiley & Sons A/S.
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pubmed:issnType |
Electronic
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
415-9
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pubmed:meshHeading |
pubmed-meshheading:21251041-Adolescent,
pubmed-meshheading:21251041-Adult,
pubmed-meshheading:21251041-Aged,
pubmed-meshheading:21251041-Child,
pubmed-meshheading:21251041-Child, Preschool,
pubmed-meshheading:21251041-Dermatofibrosarcoma,
pubmed-meshheading:21251041-Dermis,
pubmed-meshheading:21251041-Embryonic Stem Cells,
pubmed-meshheading:21251041-Female,
pubmed-meshheading:21251041-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:21251041-Hair Follicle,
pubmed-meshheading:21251041-Histiocytoma, Benign Fibrous,
pubmed-meshheading:21251041-Humans,
pubmed-meshheading:21251041-Infant,
pubmed-meshheading:21251041-Intermediate Filament Proteins,
pubmed-meshheading:21251041-Male,
pubmed-meshheading:21251041-Middle Aged,
pubmed-meshheading:21251041-Neoplasm Proteins,
pubmed-meshheading:21251041-Nerve Tissue Proteins,
pubmed-meshheading:21251041-SOXB1 Transcription Factors,
pubmed-meshheading:21251041-Skin Neoplasms,
pubmed-meshheading:21251041-Tumor Markers, Biological
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pubmed:year |
2011
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pubmed:articleTitle |
Expression of embryonic stem cell markers SOX2 and nestin in dermatofibrosarcoma protuberans and dermatofibroma.
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pubmed:affiliation |
Department of Dermatology, Cleveland Clinic Foundation, Cleveland, OH, USA. klaus.sellheyer@gmail.com
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pubmed:publicationType |
Journal Article,
Comparative Study
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