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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2011-3-1
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pubmed:abstractText |
It is known that HMG-CoA reductase inhibitors (statins) may have a therapeutic benefit in patients with heart failure (HF). However, no studies have yet evaluated the possible interaction of statins and angiotensin-II receptor blockers (ARBs) on left ventricular (LV) function in patients with HF. We hypothesized that statins might alter the effect of ARBs on cardiac function in patients with HF.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1347-4820
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
589-95
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pubmed:meshHeading |
pubmed-meshheading:21242642-Aged,
pubmed-meshheading:21242642-Angiotensin Receptor Antagonists,
pubmed-meshheading:21242642-Chronic Disease,
pubmed-meshheading:21242642-Drug Synergism,
pubmed-meshheading:21242642-Drug Therapy, Combination,
pubmed-meshheading:21242642-Electrocardiography,
pubmed-meshheading:21242642-Female,
pubmed-meshheading:21242642-Heart Failure,
pubmed-meshheading:21242642-Humans,
pubmed-meshheading:21242642-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:21242642-Losartan,
pubmed-meshheading:21242642-Male,
pubmed-meshheading:21242642-Middle Aged,
pubmed-meshheading:21242642-Prospective Studies,
pubmed-meshheading:21242642-Renin-Angiotensin System,
pubmed-meshheading:21242642-Simvastatin,
pubmed-meshheading:21242642-Treatment Outcome,
pubmed-meshheading:21242642-Ventricular Dysfunction, Left
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pubmed:year |
2011
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pubmed:articleTitle |
Synergistic effect of combined HMG-CoA reductase inhibitor and angiotensin-II receptor blocker therapy in patients with chronic heart failure: the HF-COSTAR trial.
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pubmed:affiliation |
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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