rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
|
pubmed:dateCreated |
2011-4-27
|
pubmed:abstractText |
We hypothesized that patients with Klinefelter's syndrome (KS) not only undergo X inactivation, but also that genes escape from inactivation. Their transcripts would constitute a significant difference, as male metabolism is not adapted to a 'female-like' gene dosage. We evaluated the expression of selected X-linked genes in our 41, XX(Y)* male mice to determine whether these genes escape inactivation and whether tissue-specific differences occur.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1651-2227
|
pubmed:author |
|
pubmed:copyrightInfo |
© 2011 The Author(s)/Acta Paediatrica © 2011 Foundation Acta Paediatrica.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
100
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
885-91
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pubmed:meshHeading |
pubmed-meshheading:21241365-Animals,
pubmed-meshheading:21241365-Brain,
pubmed-meshheading:21241365-Disease Models, Animal,
pubmed-meshheading:21241365-Eukaryotic Initiation Factor-2,
pubmed-meshheading:21241365-Female,
pubmed-meshheading:21241365-Gene Expression,
pubmed-meshheading:21241365-Kidney,
pubmed-meshheading:21241365-Klinefelter Syndrome,
pubmed-meshheading:21241365-Liver,
pubmed-meshheading:21241365-Male,
pubmed-meshheading:21241365-Mice,
pubmed-meshheading:21241365-Phosphoglycerate Kinase,
pubmed-meshheading:21241365-RNA, Messenger,
pubmed-meshheading:21241365-RNA Helicases,
pubmed-meshheading:21241365-X Chromosome Inactivation
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pubmed:year |
2011
|
pubmed:articleTitle |
Expression of selected genes escaping from X inactivation in the 41, XX(Y)* mouse model for Klinefelter's syndrome.
|
pubmed:affiliation |
Institute of Reproductive and Regenerative Biology, Centre of Reproductive Medicine and Andrology, University Clinics, Muenster, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|