Source:http://linkedlifedata.com/resource/pubmed/id/21237474
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2011-2-14
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| pubmed:abstractText |
Three Indian rhesus macaques, Ad-SIV primed/protein boosted and exposed twice to high-dose mucosal SIV(mac251) challenges, exhibited elite control of viremia over 6.5 years. They were negative for host factors associated with control of SIV infection. After a third intrarectal challenge with SIV(smE660), all controlled viremia, with one (macaque #5) maintaining undetectable viremia in blood. Acquisition was not blocked, but virus was contained in the jejunum and draining lymph nodes. Polyfunctional memory T cell responses and high-titered neutralizing and non-neutralizing serum and mucosal antibodies were present before and maintained post-challenge. The level of protection seen for animal #5 was predicted from analyses of gene transcription in jejunum 2 weeks post-challenge. Macaques #7 and #9, exhibiting lower pre-challenge cellular and humoral immunity, partially controlled the SIV(smE660) challenge. Initial vaccine-induced control by macaque #5 extended to the SIV(smE660) challenge due to multiple immune mechanisms that were boosted and augmented by cryptic SIV exposure.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1096-0341
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| pubmed:author |
pubmed-author:Brocca-CofanoEgidioE,
pubmed-author:Daltabuit-TestMaraM,
pubmed-author:DandekarSatyaS,
pubmed-author:HirschVanessaV,
pubmed-author:HuWilliamW,
pubmed-author:KaliszIreneI,
pubmed-author:KalyanaramanV SVS,
pubmed-author:LeeEun MiEM,
pubmed-author:MontefioriDavid CDC,
pubmed-author:PalRanajitR,
pubmed-author:PattersonL JeanLJ,
pubmed-author:Robert-GuroffMarjorieM,
pubmed-author:RoedererMarioM,
pubmed-author:SederRobertR,
pubmed-author:WhitneyStephenS,
pubmed-author:Wille-ReeceUlrikeU,
pubmed-author:WisemanRoger WRW,
pubmed-author:XiaoPengP,
pubmed-author:ZhaoJunJ
|
| pubmed:copyrightInfo |
Published by Elsevier Inc.
|
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
411
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
87-102
|
| pubmed:meshHeading |
pubmed-meshheading:21237474-Animals,
pubmed-meshheading:21237474-Antibodies, Neutralizing,
pubmed-meshheading:21237474-Antibodies, Viral,
pubmed-meshheading:21237474-Immunity, Cellular,
pubmed-meshheading:21237474-Immunity, Mucosal,
pubmed-meshheading:21237474-Jejunum,
pubmed-meshheading:21237474-Lymph Nodes,
pubmed-meshheading:21237474-Macaca mulatta,
pubmed-meshheading:21237474-Serum,
pubmed-meshheading:21237474-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:21237474-Simian immunodeficiency virus,
pubmed-meshheading:21237474-T-Lymphocytes,
pubmed-meshheading:21237474-Viremia
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Rapid SIV Env-specific mucosal and serum antibody induction augments cellular immunity in protecting immunized, elite-controller macaques against high dose heterologous SIV challenge.
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| pubmed:affiliation |
Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
|