Diabetic cardiomyopathy, characterized by myocardial structural and functional changes, is a specific cardiomyopathy develops in patients with diabetes mellitus. The present study was to investigate the role of kinin B2 receptor-Akt-glycogen synthase kinase (GSK)-3? signalling pathway in mediating the protective effects of tanshinone IIA (TSN) on diabetic cardiomyopathy.