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rdf:type |
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lifeskim:mentions |
umls-concept:C0001779,
umls-concept:C0004083,
umls-concept:C0026882,
umls-concept:C0032105,
umls-concept:C0033684,
umls-concept:C0168913,
umls-concept:C0332162,
umls-concept:C0441889,
umls-concept:C0678951,
umls-concept:C1742737,
umls-concept:C1823367
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pubmed:issue |
5
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pubmed:dateCreated |
2011-5-10
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pubmed:abstractText |
To test whether rs1990622 (TMEM106B) is associated with age at onset (AAO) in granulin (GRN) mutation carriers and with plasma GRN levels in mutation carriers and healthy, elderly individuals. Rs1990622 (TMEM106B) was identified as a risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein inclusions (FTLD-TDP) in a recent genome-wide association.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1538-3687
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pubmed:author |
pubmed-author:BertelsenSarahS,
pubmed-author:ChiangHuei-HsinHH,
pubmed-author:CruchagaCarlosC,
pubmed-author:GoateAlisonA,
pubmed-author:GraffCarolineC,
pubmed-author:HinrichsAnthony LAL,
pubmed-author:MayoKevinK,
pubmed-author:MorrisJohn CJC,
pubmed-author:NortonJoanne BJB,
pubmed-author:SpiegelNoahN,
pubmed-author:WangJunJ
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pubmed:issnType |
Electronic
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
581-6
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:21220649-Age of Onset,
pubmed-meshheading:21220649-Aged,
pubmed-meshheading:21220649-Alzheimer Disease,
pubmed-meshheading:21220649-Amino Acid Substitution,
pubmed-meshheading:21220649-Female,
pubmed-meshheading:21220649-Frontotemporal Lobar Degeneration,
pubmed-meshheading:21220649-Gene Expression,
pubmed-meshheading:21220649-Genetic Predisposition to Disease,
pubmed-meshheading:21220649-Heterozygote,
pubmed-meshheading:21220649-Humans,
pubmed-meshheading:21220649-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:21220649-Kaplan-Meier Estimate,
pubmed-meshheading:21220649-Linkage Disequilibrium,
pubmed-meshheading:21220649-Male,
pubmed-meshheading:21220649-Membrane Proteins,
pubmed-meshheading:21220649-Middle Aged,
pubmed-meshheading:21220649-Mutation,
pubmed-meshheading:21220649-Nerve Tissue Proteins,
pubmed-meshheading:21220649-Polymorphism, Single Nucleotide,
pubmed-meshheading:21220649-Proportional Hazards Models,
pubmed-meshheading:21220649-Risk Assessment,
pubmed-meshheading:21220649-Risk Factors,
pubmed-meshheading:21220649-Serine,
pubmed-meshheading:21220649-Threonine,
pubmed-meshheading:21220649-Time Factors
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pubmed:year |
2011
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pubmed:articleTitle |
Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.
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pubmed:affiliation |
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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