Linked Life Data

2121199

Source:http://linkedlifedata.com/resource/pubmed/id/2121199

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1990-12-10
pubmed:abstractText
Alteplase (recombinant tissue-type plasminogen activator (rt-PA)) was infused within four hours of onset of symptoms in 286 patients with acute myocardial infarction. Delayed coronary angiography was performed 72 hours after admission with coronary angioplasty if indicated. Electrocardiographic monitoring was continuous during the first hour of treatment. The sum of the ST segment elevations (sigma ST) was calculated on electrocardiograms recorded at entry and an hour later. ST elevations resolved rapidly within one hour of treatment in 189 patients and persisted in 97 patients. Rapid resolution of ST elevation correlated with angiographic coronary patency as determined by coronary angiography 72 hours after admission. The patients with rapid resolution of sigma ST had significantly smaller infarcts and a better clinical outcome than the patients with persistent ST elevation. sigma ST values at entry and one hour after treatment had no additional independent predictive value. Rapid resolution of ST elevations in patients undergoing thrombolysis with alteplase was associated with a significantly smaller release of creatine kinase, better preservation of left ventricular function, lower morbidity, and less short and long term mortality. Rapid resolution of sigma ST elevation is an efficient indicator of clinical outcome in groups of patients with acute myocardial infarction undergoing thrombolysis with alteplase.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-2893037, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-2956516, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-3190955, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-3285216, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-3825886, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-3962892, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-3982468, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-4015917, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-4058533, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-6341843, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-6702612, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-6711421, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-6778627, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-6831668, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-6861316, http://linkedlifedata.com/resource/pubmed/commentcorrection/2121199-7460232
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0007-0769
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
241-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Rapid resolution of ST elevation and prediction of clinical outcome in patients undergoing thrombolysis with alteplase (recombinant tissue-type plasminogen activator): results of the Israeli Study of Early Intervention in Myocardial Infarction.
pubmed:affiliation
Cardiology Department, Sheba Medical Center, Tel Hashomer, Israel.
pubmed:publicationType
Journal Article, Clinical Trial