Linked Life Data

21205430

Source:http://linkedlifedata.com/resource/pubmed/id/21205430

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2011-4-28
pubmed:abstractText
The activation of PPAR? by ligands, including conjugated linoleic acid (CLA) isomers, plays an important role in the immune response. Among CLA isomers, trans-10, cis-12 (t10c12)-CLA is known to participate in the modulation of pro-inflammatory cytokine secretion. The aim of the present study was to assess the effect of t10c12-CLA on PPAR? activation, NF-?B activation and TNF-? expression in lipopolysaccharide (LPS)-naive and LPS-stimulated porcine peripheral blood mononuclear cells (PBMC). In addition, the effect of PPAR? inhibition on NF-?B activation and TNF-? expression in porcine PBMC was examined. t10c12-CLA was found to increase TNF-? expression and NF-?B activity in LPS-naive porcine PBMC. In contrast, t10c12-CLA decreased TNF-? expression and NF-?B activity in LPS-stimulated porcine PBMC. t10c12-CLA up-regulated PPAR? activity and mRNA expression in both LPS-naive and LPS-stimulated porcine PBMC. GW9662, a PPAR? antagonist, completely negated the modulating effects of t10c12-CLA on TNF-? expression and NF-?B activity in both LPS-naive and LPS-stimulated porcine PBMC. These results suggest that t10c12-CLA can modulate TNF-? production and NF-?B activation by a PPAR?-dependent pathway in porcine PBMC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1475-2662
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1329-36
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Trans-10, cis-12-conjugated linoleic acid modulates NF-?B activation and TNF-? production in porcine peripheral blood mononuclear cells via a PPAR?-dependent pathway.
pubmed:affiliation
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't