Linked Life Data

21192933

Source:http://linkedlifedata.com/resource/pubmed/id/21192933

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2011-1-17
pubmed:abstractText
S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NF?B activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NF?B activation, TNF?-induced IL-8 gene expression and NF?B p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1873-3468
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
585
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
440-6
pubmed:meshHeading
pubmed:year
2011
pubmed:articleTitle
Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation.
pubmed:affiliation
Institute of Immunology, University of Muenster, Muenster, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't