Linked Life Data

21189395

Source:http://linkedlifedata.com/resource/pubmed/id/21189395

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2011-3-1
pubmed:abstractText
Approximately 35% of HER2-amplified breast cancers have coamplification of the topoisomerase II-alpha (TOP2A) gene encoding an enzyme that is a major target of anthracyclines. This study was designed to evaluate whether TOP2A gene alterations may predict incremental responsiveness to anthracyclines in some breast cancers.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1527-7755
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
859-67
pubmed:dateRevised
2011-9-2
pubmed:meshHeading
pubmed-meshheading:21189395-Adult, pubmed-meshheading:21189395-Aged, pubmed-meshheading:21189395-Anthracyclines, pubmed-meshheading:21189395-Antigens, Neoplasm, pubmed-meshheading:21189395-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:21189395-Breast Neoplasms, pubmed-meshheading:21189395-DNA Topoisomerases, Type II, pubmed-meshheading:21189395-DNA-Binding Proteins, pubmed-meshheading:21189395-Disease-Free Survival, pubmed-meshheading:21189395-Female, pubmed-meshheading:21189395-Gene Amplification, pubmed-meshheading:21189395-Gene Expression Regulation, Neoplastic, pubmed-meshheading:21189395-Genes, erbB-2, pubmed-meshheading:21189395-Genetic Predisposition to Disease, pubmed-meshheading:21189395-Humans, pubmed-meshheading:21189395-In Situ Hybridization, Fluorescence, pubmed-meshheading:21189395-Middle Aged, pubmed-meshheading:21189395-Prognosis, pubmed-meshheading:21189395-Proportional Hazards Models, pubmed-meshheading:21189395-Risk Assessment, pubmed-meshheading:21189395-Statistics, Nonparametric, pubmed-meshheading:21189395-Survival Analysis, pubmed-meshheading:21189395-Treatment Outcome
pubmed:year
2011
pubmed:articleTitle
Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy.
pubmed:affiliation
Norris Comprehensive Cancer Center, University of Southern California, CA, USA. press@usc.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S., Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Clinical Trial, Phase III, Research Support, N.I.H., Extramural