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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
Calcium/calmodulin-dependent protein kinase (CaMK) II and its downstream effector cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB) may be involved in the development of neuropathic pain. The aim of this study was to examine the effect of the CaMKII inhibitor AIP on the association of CaMKII and CREB in a partial sciatic nerve ligation neuropathic pain model in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1438-8359
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
87-92
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pubmed:meshHeading |
pubmed-meshheading:21188428-Animals,
pubmed-meshheading:21188428-Blotting, Western,
pubmed-meshheading:21188428-Calcium-Calmodulin-Dependent Protein Kinase Type 2,
pubmed-meshheading:21188428-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:21188428-Down-Regulation,
pubmed-meshheading:21188428-Hyperalgesia,
pubmed-meshheading:21188428-Immunohistochemistry,
pubmed-meshheading:21188428-Male,
pubmed-meshheading:21188428-Neuralgia,
pubmed-meshheading:21188428-Pain Threshold,
pubmed-meshheading:21188428-Phosphorylation,
pubmed-meshheading:21188428-Physical Stimulation,
pubmed-meshheading:21188428-Protein Kinase Inhibitors,
pubmed-meshheading:21188428-Rats,
pubmed-meshheading:21188428-Rats, Sprague-Dawley,
pubmed-meshheading:21188428-Spinal Cord
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pubmed:year |
2011
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pubmed:articleTitle |
Anti-hyperalgesic effect of CaMKII inhibitor is associated with downregulation of phosphorylated CREB in rat spinal cord.
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pubmed:affiliation |
Department of Anesthesiology, Gongli Hospital, Pudong, Shanghai, China.
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pubmed:publicationType |
Journal Article
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