Source:http://linkedlifedata.com/resource/pubmed/id/21187171
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0002482,
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umls-concept:C1704632,
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umls-concept:C1883254,
umls-concept:C2911692
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| pubmed:issue |
4
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| pubmed:dateCreated |
2011-3-1
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| pubmed:abstractText |
The synthesis of a new family of biodegradable ?-amino acid poly(ester amide)s (AA-PEAs) with pendant benzyl ether groups and hydroxyl functional groups is reported. The synthetic strategy employs the ring opening reaction of O-benzyl-L-serine-N-carboxyanhydride with di-p-toluenesulfonic acid salts of bis-L-valine butane-1,4-diester, followed by solution polycondesation reactions with di-p-nitrophenyl sebacate in N,N-dimethylacetamide. Catalytic hydrogenation of the resulting benzyl ether protected AA-PEAs (PEA-Ser-Bzs) was performed to restore the hydroxyl functional groups in the functionalized AA-PEAs (PEA-Ser-OH). All resulting polymers were characterized by standard physico-chemical methods. The pendant hydroxyl groups in PEA-Ser-OH were used to fabricate AA-PEA-based gels via acrylation and photo-gelation. The cell-polymer interactions of PEA-Ser-Bz and PEA-Ser-OH were evaluated in terms of cell attachment and proliferation assay using bovine aortic endothelial cells (BAECs) as well as fibroblasts. The cell culture data indicated that the hydrophobic/hydrophilic characteristics (from contact angle data) of these AA-PEAs could significantly affect the interaction between BAECs and AA-PEA. This finding may provide additional possible applications for this new family of functionalized AA-PEA polymers.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1878-7568
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
7
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1504-15
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| pubmed:meshHeading |
pubmed-meshheading:21187171-Amides,
pubmed-meshheading:21187171-Amino Acids,
pubmed-meshheading:21187171-Animals,
pubmed-meshheading:21187171-Biodegradation, Environmental,
pubmed-meshheading:21187171-Calorimetry, Differential Scanning,
pubmed-meshheading:21187171-Cattle,
pubmed-meshheading:21187171-Cell Adhesion,
pubmed-meshheading:21187171-Cell Proliferation,
pubmed-meshheading:21187171-Endothelial Cells,
pubmed-meshheading:21187171-Fibroblasts,
pubmed-meshheading:21187171-Humans,
pubmed-meshheading:21187171-Hydroxyl Radical,
pubmed-meshheading:21187171-Magnetic Resonance Spectroscopy,
pubmed-meshheading:21187171-Materials Testing,
pubmed-meshheading:21187171-Polyesters,
pubmed-meshheading:21187171-Solubility,
pubmed-meshheading:21187171-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:21187171-Temperature
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| pubmed:year |
2011
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| pubmed:articleTitle |
Biodegradable functional poly(ester amide)s with pendant hydroxyl functional groups: synthesis, characterization, fabrication and in vitro cellular response.
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| pubmed:affiliation |
Department of Fiber Science and Apparel Design, Cornell University, Ithaca, NY 14853, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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