| pubmed-article:21176845 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21176845 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:21176845 | lifeskim:mentions | umls-concept:C0039215 | lld:lifeskim |
| pubmed-article:21176845 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:21176845 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:21176845 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:21176845 | lifeskim:mentions | umls-concept:C1744214 | lld:lifeskim |
| pubmed-article:21176845 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21176845 | pubmed:dateCreated | 2011-1-28 | lld:pubmed |
| pubmed-article:21176845 | pubmed:abstractText | The phenotypic changes that are induced by immune activation in CD4(+) T lymphocytes provide an optimal environment for efficient HIV-1 replication in these cells. The pathogenic Nef protein of HIV-1 modulates the T cell receptor (TCR) signaling, but whether this has a positive or negative effect on cellular activation is a matter of debate. Here we have investigated the response to TCR stimulation of primary CD4(+) T lymphocytes infected with wt or Nef-deficient HIV-1. Results show that, in freshly isolated quiescent T cells, Nef superinduces NFAT and IL-2 production bypassing early TCR effector molecules. Conversely, the early phosphorylation of PLC-?1, the induction of NFAT, and the expression of IL-2 are impaired by Nef in sub-optimally activated/resting T cells. Our data indicate that Nef has a dual role in the modulation of TCR signaling aimed at favoring HIV-1 replication and spread in both quiescent and metabolically active CD4(+) T lymphocytes. | lld:pubmed |
| pubmed-article:21176845 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21176845 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21176845 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21176845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21176845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21176845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21176845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21176845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21176845 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21176845 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21176845 | pubmed:issn | 1096-0341 | lld:pubmed |
| pubmed-article:21176845 | pubmed:author | pubmed-author:NeriFrancesca... | lld:pubmed |
| pubmed-article:21176845 | pubmed:author | pubmed-author:DoriaMargheri... | lld:pubmed |
| pubmed-article:21176845 | pubmed:author | pubmed-author:PetriniStefan... | lld:pubmed |
| pubmed-article:21176845 | pubmed:author | pubmed-author:PotestàMarina... | lld:pubmed |
| pubmed-article:21176845 | pubmed:author | pubmed-author:GioloGiorgiaG | lld:pubmed |
| pubmed-article:21176845 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21176845 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21176845 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:21176845 | pubmed:volume | 410 | lld:pubmed |
| pubmed-article:21176845 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21176845 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21176845 | pubmed:pagination | 316-26 | lld:pubmed |
| pubmed-article:21176845 | pubmed:meshHeading | pubmed-meshheading:21176845... | lld:pubmed |
| pubmed-article:21176845 | pubmed:meshHeading | pubmed-meshheading:21176845... | lld:pubmed |
| pubmed-article:21176845 | pubmed:meshHeading | pubmed-meshheading:21176845... | lld:pubmed |
| pubmed-article:21176845 | pubmed:meshHeading | pubmed-meshheading:21176845... | lld:pubmed |
| pubmed-article:21176845 | pubmed:meshHeading | pubmed-meshheading:21176845... | lld:pubmed |
| pubmed-article:21176845 | pubmed:meshHeading | pubmed-meshheading:21176845... | lld:pubmed |
| pubmed-article:21176845 | pubmed:meshHeading | pubmed-meshheading:21176845... | lld:pubmed |
| pubmed-article:21176845 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21176845 | pubmed:articleTitle | The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes. | lld:pubmed |
| pubmed-article:21176845 | pubmed:affiliation | Laboratory of Immunoinfectivology, Children's Hospital Bambino Gesù, 00165 Rome, Italy. | lld:pubmed |
| pubmed-article:21176845 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:156110 | entrezgene:pubmed | pubmed-article:21176845 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21176845 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21176845 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21176845 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21176845 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21176845 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21176845 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21176845 | lld:entrezgene |
