| pubmed-article:2117510 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0333516 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C1819433 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0444706 | lld:lifeskim |
| pubmed-article:2117510 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:2117510 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2117510 | pubmed:dateCreated | 1990-9-27 | lld:pubmed |
| pubmed-article:2117510 | pubmed:abstractText | The spot-ELISA technique has been used to enumerate the frequency of cells secreting tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma), isolated from biopsies of normal intestine and from biopsies of children with inflammatory bowel disease. TNF-alpha production was undetectable in six out of 12 biopsies from normal intestine and in the other six biopsies it ranged from 60 to 580 TNF-alpha-secreting cells/10(6) isolated intestinal cells. In contrast, cells isolated from biopsies of children with Crohn's disease (n = 9) all showed elevated frequencies of TNF-alpha-secreting cells (500-12,000 secreting cells/10(6) cells). In ulcerative colitis, four out of eight children had increased production of TNF-alpha and in children with indeterminate colitis two out of three had elevated levels. There was no correlation between plasma TNF-alpha levels and the number of intestinal cells secreting TNF-alpha. In controls and all groups of patients IFN-gamma-secreting cells were uncommon. These results suggest that TNF-alpha is an important mediator of inflammation in the human gut, and, furthermore, may play a role in the growth failure frequently seen in children with inflammatory bowel disease. | lld:pubmed |
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| pubmed-article:2117510 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2117510 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2117510 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2117510 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2117510 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2117510 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:2117510 | pubmed:author | pubmed-author:MacDonaldT... | lld:pubmed |
| pubmed-article:2117510 | pubmed:author | pubmed-author:CookeAA | lld:pubmed |
| pubmed-article:2117510 | pubmed:author | pubmed-author:HutchingsPP | lld:pubmed |
| pubmed-article:2117510 | pubmed:author | pubmed-author:ChoyM YMY | lld:pubmed |
| pubmed-article:2117510 | pubmed:author | pubmed-author:MurchSS | lld:pubmed |
| pubmed-article:2117510 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2117510 | pubmed:volume | 81 | lld:pubmed |
| pubmed-article:2117510 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2117510 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2117510 | pubmed:pagination | 301-5 | lld:pubmed |
| pubmed-article:2117510 | pubmed:dateRevised | 2010-8-25 | lld:pubmed |
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| pubmed-article:2117510 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2117510 | pubmed:articleTitle | Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. | lld:pubmed |
| pubmed-article:2117510 | pubmed:affiliation | Department of Paediatric Gastroenterology, St Bartholomew's Hospital, London, England. | lld:pubmed |
| pubmed-article:2117510 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2117510 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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