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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-5
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pubmed:abstractText |
The establishment of neuronal circuits relies on the stabilization of functionally appropriate connections and the elimination of inappropriate ones. Here we report that postsynaptic AMPA receptors play a critical role in regulating the stability of glutamatergic synapses. Removal of surface AMPA receptors leads to a decrease in the number and stability of excitatory presynaptic inputs, whereas overexpression increases synapse number and stability. Furthermore, overexpression of AMPA receptors along with Neuroligin-1 in 293T cells is sufficient to stabilize presynaptic inputs from cortical neurons onto heterologous cells. The stabilization of presynaptic inputs by AMPA receptors is not dependent on receptor-mediated current and instead relies on structural interactions mediated by the N-terminal domain of the glutamate receptor 2 (GluR2) subunit. These observations indicate that transsynaptic signaling mediated by the extracellular domain of GluR2 regulates the stability of presynaptic terminals.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-10202544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-10769383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-10892652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-10939331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-11092446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-11182086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-11348590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-12089529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-12202822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-12399581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-12490942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-12490949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-12718858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-12904794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-12907306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-16139911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-16807326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-16882725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-16980967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-16982420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17050720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17122040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17145504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17237775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17254766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17329203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17481397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17481398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17506699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-17537978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-18057203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-19285470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-19409270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-20064387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-20064388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-20547129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-7646894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-7753197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-7760933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-7800815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-9052797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-9331353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/21173224-9786995
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-72
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:21173224-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:21173224-Cell Line,
pubmed-meshheading:21173224-Dendritic Spines,
pubmed-meshheading:21173224-Electrophysiology,
pubmed-meshheading:21173224-Humans,
pubmed-meshheading:21173224-Immunohistochemistry,
pubmed-meshheading:21173224-Receptors, AMPA,
pubmed-meshheading:21173224-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:21173224-Signal Transduction,
pubmed-meshheading:21173224-Synapses
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pubmed:year |
2011
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pubmed:articleTitle |
Regulation of synaptic stability by AMPA receptor reverse signaling.
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pubmed:affiliation |
Neurobiology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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