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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-20
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pubmed:abstractText |
Human subjects and Old World primates have high levels of antibody to galactose-?-1,3 galactose ?-1,4-N-acetylglucosamine (?-Gal). Commercially available bioprosthetic heart valves of porcine and bovine origin retain the Gal antigen despite current processing techniques. Gal-deficient pigs eliminate this xenoantigen. This study tests whether binding of human anti-Gal antibody effects calcification of wild-type and Gal-deficient glutaraldehyde-fixed porcine pericardium by using a standard subcutaneous implant model.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Heterophile,
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Fixatives,
http://linkedlifedata.com/resource/pubmed/chemical/Galactosyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Glutaral,
http://linkedlifedata.com/resource/pubmed/chemical/Griffonia simplicifolia lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Trisaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-1,3-galactosyltransferase 1...,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-galactosyl epitope
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2011 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
269-75
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pubmed:dateRevised |
2011-8-8
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pubmed:meshHeading |
pubmed-meshheading:21168032-Animals,
pubmed-meshheading:21168032-Animals, Genetically Modified,
pubmed-meshheading:21168032-Antigens, Heterophile,
pubmed-meshheading:21168032-Autoantibodies,
pubmed-meshheading:21168032-Bioprosthesis,
pubmed-meshheading:21168032-Calcinosis,
pubmed-meshheading:21168032-Fixatives,
pubmed-meshheading:21168032-Galactosyltransferases,
pubmed-meshheading:21168032-Glutaral,
pubmed-meshheading:21168032-Heart Valve Prosthesis,
pubmed-meshheading:21168032-Heart Valve Prosthesis Implantation,
pubmed-meshheading:21168032-Humans,
pubmed-meshheading:21168032-Microscopy, Fluorescence,
pubmed-meshheading:21168032-Pericardium,
pubmed-meshheading:21168032-Plant Lectins,
pubmed-meshheading:21168032-Prosthesis Design,
pubmed-meshheading:21168032-Rabbits,
pubmed-meshheading:21168032-Rats,
pubmed-meshheading:21168032-Rats, Wistar,
pubmed-meshheading:21168032-Swine,
pubmed-meshheading:21168032-Time Factors,
pubmed-meshheading:21168032-Transplantation, Heterologous,
pubmed-meshheading:21168032-Trisaccharides
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pubmed:year |
2011
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pubmed:articleTitle |
Cardiac xenotransplantation technology provides materials for improved bioprosthetic heart valves.
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pubmed:affiliation |
Department of Cardiothoracic Surgery, University College London, London, United Kingdom. mcgregor.christopher@mayo.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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