Source:http://linkedlifedata.com/resource/pubmed/id/21147757
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2011-4-7
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| pubmed:abstractText |
Four new steroidal glycosides such as 3-O-6-deoxy-3-O-methyl-?-D-allopyranosyl-(1 ? 4)-?-D-oleandropyranosyl-(1 ? 4)-?-D-cymaropyranosyl-(1 ? 4)-?-D-cymaropyranoside-12-?-tigloyl-14-?-hydroxy-17-?-pregnane (1), 3-O-6-deoxy-3-O-methyl-?-D-allopyranosyl-(1 ? 4)-?-D-oleandropyranosyl-(1 ? 4)-?-D-cymaropyranosyl-(1 ? 4)-?-D-cymaropyranoside-12-?-(2'-amino)-benzoyl-14-?-hydroxy-17-?-pregnane (2), 3-O-6-deoxy-3-O-methyl-?-D-allopyranosyl-(1 ? 4)-?-D-oleandropyranosyl-(1 ? 4)-?-D-cymaropyranosyl-(1 ? 4)-?-D-cymaropyranoside-12-?-14-?-dihydroxy-17-?-pregnane (3) and 3-O-6-deoxy-3-O-methyl-?-D-allopyranosyl-(1 ? 4)-?-D-oleandropyranosyl-(1 ? 4)-?-D-cymaropyranosyl-(1 ? 4)-?-D-cymaropyranoside-12-?-14-?-dihydroxy-17-?-pregnane (4) were isolated from the aerial parts of Ceropegia fusca Bolle (Asclepiadaceae), a crassulacean acid metabolism plant, an endemic species to the Canary Islands that has been used in traditional medicine as a cicatrizant, vulnerary and disinfectant. The dichloromethane extract exhibited significant cytostatic activity against HL-60, A-431 and SK-MEL-1 cells, human leukemic, epidermoid carcinoma and melanoma cells, respectively. As shown in Table I, compounds 1 and 2 showed very similar IC(50) values. The acetylation of 1 to give the diacetate 5 increases 5-fold the cytotoxicity against HL-60 cells. Compounds 3 and 4 did not show cytotoxicity at the assayed concentrations. With respect to the compounds containing only the steroid ring (6-8), the presence of a charged O-amino-benzoyl but not a tigloyl group improved the cytotoxicity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cytostatic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosides,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Pregnanes
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
|
| pubmed:issn |
1460-2423
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
619-24
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| pubmed:meshHeading |
pubmed-meshheading:21147757-Antineoplastic Agents,
pubmed-meshheading:21147757-Apoptosis,
pubmed-meshheading:21147757-Cell Cycle,
pubmed-meshheading:21147757-Cell Line, Tumor,
pubmed-meshheading:21147757-Cell Proliferation,
pubmed-meshheading:21147757-Cell Shape,
pubmed-meshheading:21147757-Cell Survival,
pubmed-meshheading:21147757-Cytostatic Agents,
pubmed-meshheading:21147757-Drug Screening Assays, Antitumor,
pubmed-meshheading:21147757-Gentiana,
pubmed-meshheading:21147757-Glycosides,
pubmed-meshheading:21147757-Humans,
pubmed-meshheading:21147757-Inhibitory Concentration 50,
pubmed-meshheading:21147757-Molecular Structure,
pubmed-meshheading:21147757-Plant Components, Aerial,
pubmed-meshheading:21147757-Plant Extracts,
pubmed-meshheading:21147757-Pregnanes,
pubmed-meshheading:21147757-Structure-Activity Relationship
|
| pubmed:year |
2011
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| pubmed:articleTitle |
Pregnane steroidal glycosides and their cytostatic activities.
|
| pubmed:affiliation |
Departamento de Química de Productos Naturales y Biotecnología, Instituto de Productos Naturales y Agrobiología de Canarias, La Laguna, Tenerife, Canary Islands. vpergarw@gobiernodecanarias.org
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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