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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-17
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pubmed:abstractText |
Sézary syndrome (SS) has a poor prognosis and few guidelines for optimizing therapy. The US Cutaneous Lymphoma Consortium, to improve clinical care of patients with SS and encourage controlled clinical trials of promising treatments, undertook a review of the published literature on therapeutic options for SS. An overview of the immunopathogenesis and standardized review of potential current treatment options for SS including metabolism, mechanism of action, overall efficacy in mycosis fungoides and SS, and common or concerning adverse effects is first discussed. The specific efficacy of each treatment for SS, both as monotherapy and combination therapy, is then reported using standardized criteria for both SS and response to therapy with the type of study defined by a modification of the US Preventive Services guidelines for evidence-based medicine. Finally, guidelines for the treatment of SS and suggestions for adjuvant treatment are noted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-6787
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pubmed:author |
pubmed-author:AdvaniRanjanaR,
pubmed-author:CacchioPatrickP,
pubmed-author:DemierreMarie-FranceMF,
pubmed-author:DuvicMadeleineM,
pubmed-author:FossFrancineF,
pubmed-author:Junkins-HopkinsJacqueline MJM,
pubmed-author:KimEllen JEJ,
pubmed-author:KimYounY,
pubmed-author:OlsenElise AEA,
pubmed-author:ParkerSareetaS,
pubmed-author:Pinter-BrownLaurenL,
pubmed-author:PittelkowMarkM,
pubmed-author:PorcuPierluigiP,
pubmed-author:QuerfeldChristianeC,
pubmed-author:RookAlain HAH,
pubmed-author:WilsonLynn DLD,
pubmed-author:WoodGaryG,
pubmed-author:ZicJohnJ
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pubmed:copyrightInfo |
Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
352-404
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pubmed:meshHeading |
pubmed-meshheading:21145619-Alkylating Agents,
pubmed-meshheading:21145619-Antibodies, Monoclonal,
pubmed-meshheading:21145619-Antineoplastic Agents,
pubmed-meshheading:21145619-Clinical Trials as Topic,
pubmed-meshheading:21145619-Combined Modality Therapy,
pubmed-meshheading:21145619-Drug Therapy, Combination,
pubmed-meshheading:21145619-Evidence-Based Medicine,
pubmed-meshheading:21145619-Histone Deacetylase Inhibitors,
pubmed-meshheading:21145619-Humans,
pubmed-meshheading:21145619-Immunologic Factors,
pubmed-meshheading:21145619-Methotrexate,
pubmed-meshheading:21145619-Mycosis Fungoides,
pubmed-meshheading:21145619-Quality of Life,
pubmed-meshheading:21145619-Retinoids,
pubmed-meshheading:21145619-Sezary Syndrome,
pubmed-meshheading:21145619-Skin Neoplasms
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pubmed:year |
2011
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pubmed:articleTitle |
Sézary syndrome: immunopathogenesis, literature review of therapeutic options, and recommendations for therapy by the United States Cutaneous Lymphoma Consortium (USCLC).
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pubmed:affiliation |
Duke University Medical Center, Durham, NC, USA. olsen001@mc.duke.edu
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pubmed:publicationType |
Journal Article,
Review
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